Effects of topically applied capsaicin on moderate and severe psoriasis vulgaris
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2021, Brain, Behavior, and Immunity - HealthCitation Excerpt :In addition to psoriasis, cutaneous sensory nerves are involved in other skin conditions such as allergic contact dermatitis (mouse model) and pruritus (Prignano et al., 2009; Wilson et al., 2011; Liu et al., 2013; Therene et al., 2018). Topical capsaicin led to depletion of sensory neuropeptides with repeated application-efficient in minimizing both psoriasis-associated skin lesions as well as cutaneous discomfort, albeit with initial burning as a side-effect (Bernstein et al., 1986). Although psoriasis treatments generally improve pruritus, this does not always correlate with lesion regression (Prignano et al., 2009; Therene et al., 2018).
Capsaicin attenuates imiquimod-induced epidermal hyperplasia and cutaneous inflammation in a murine model of psoriasis
2021, Biomedicine and PharmacotherapyCitation Excerpt :Results show that IL-23 production after imiquimod stimulation could be inhibited by topical application of capsaicin which arrests TRPV1 pathway, and this inhibition effect on psoriasiform inflammation could be by-passed by direct cutaneous injection of IL-23. These results serve as a potential expounder for an earlier clinical observation that topical capsaicin is able to bring improvement in a patient with psoriasis vulgaris [19]. The improvement of psoriasiform inflammation simply by epicutaneous delivery of capsaicin proposes a readily available, non-steroidal product with a high safety profile in treating psoriasiform dermatitis.
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