III, 1. Aspects of the molecular biology of enteric adenoviruses

https://doi.org/10.1016/S0168-7069(03)09024-4Get rights and content

Abstract

The enteric adenoviruses display a very restricted host range phenotype in tissue culture and, as previously reviewed (Mautner et al., 1995), this is a complex and poorly understood phenomenon. In this chapter we have described some properties of the Ad40 E1A region, which suggest that the basal activity of the E1A promoter, and the activity of the E1A 249R protein are limited in cell lines normally permissive for adenovirus propagation. A fuller understanding of the potential of Ad40 will require the development of gut cell cultures, which more closely mirror the conditions found in the intestine.

The work described in this chapter was carried out while the authors were in the Medical Research Council Virology Unit, Institute of Virology, Glasgow G11 5JR, SCOTLAND.

References (89)

  • P. Hearing et al.

    The adenovirus type 5 ElA enhancer contains two functionally distinct domains: One is specific for EIA and the other modulates all early units in cis

    Cell

    (1986)
  • T. Hoey et al.

    Isolation and characterization of the Drosophila gene encoding the TATA box binding protein, TFIID

    Cell

    (1990)
  • M. Ishino et al.

    Characterisation of adenovirus type 40 El region

    Virology

    (1988)
  • E.N. Janoff et al.

    Adenovirus colitis in the acquired immunodeficiency syndrome

    Gastroenterology

    (1991)
  • A.H. Kidd et al.

    Adenovirus type 40 contains two distinct fibers

    Virology

    (1993)
  • V. Mautner et al.

    Complementation of enteric adenovirus type 40 for lytic growth in tissue culture by ElB 55K function of adenovirus types 5 and 12

    Virology

    (1989)
  • V. Mautner et al.

    Enteric adenovirus type 40: Expression of EIB mRNA and proteins in permissive and nonpermissive cells

    Virology

    (1990)
  • V. Mautner et al.

    Properties of the adenovirus type 40 ElB promoter that contribute to its low transcriptional activity

    Virology

    (1999)
  • S.J. Richmond et al.

    An outbreak of gastroenteritis in young children caused by adenoviruses

    Lancet

    (1979)
  • W.J. Rodriguez et al.

    Faecal adenoviruses from a longitudinal study of families in metropolitan Washington DC: laboratory, clinical and epidemiology observations

    J. Pediatr

    (1985)
  • D.J. Spector et al.

    A multicomponent cis-activator of transcription of the E1B gene of adenovirus type 5

    Virology

    (1993)
  • V. Steinthorsdottir et al.

    Enteric adenovirus type 40: EIB transcription map and novel ElA-ElB co-transcripts in lytically infected cells

    Virology

    (1991)
  • H.E. Takiff et al.

    Propagation and in vitro studies of previously non-cultivable enteral adenovirus in 293 cells

    Lancet

    (1981)
  • C.T. Tiemessen et al.

    Adenovirus 41 replication: Cell-related differences in viral gene transcription

    Mol. Cell. Probes

    (1996)
  • H.G.A.M. van der Avoort et al.

    Characterisation of fastidious adenovirus types 40 and 41 by DNA restriction enzyme analysis and by neutralising monoclonal antibodies

    Virus Res

    (1989)
  • A.E. van Loon et al.

    Cell transformation of the left terminal regions of the adenovirus 40 and 41 genomes

    Virology

    (1985)
  • A.E. van Loon et al.

    Structure and organisation of the left-terminal DNA regions of fastidious adenovirus types 40 and 41

    Gene

    (1987)
  • A.E. van Loon et al.

    Transcriptional activation by the EIA regions of adenovirus types 40 and 41

    Virology

    (1987)
  • C.P. Verrijzer et al.

    Binding of TAFs to core elements directs promoter selectivity by RNA polymerase II

    Cell

    (1995)
  • A. Whitelaw et al.

    Electron microscopy of fatal adenovirus gastroenteritis

    Lancet

    (1977)
  • R.H. Yolken et al.

    Gastroenteritis associated with enteric type adenovirus in hospitalised infants

    J. Paediatr

    (1982)
  • T. Adrian et al.

    DNA restriction analysis of adenovirus prototypes 1 to 41

    Arch. Virol

    (1986)
  • A. Allard et al.

    Rapid typing of human adenoviruses by a general PCR combined with restriction endonuclease analysis

    J Clin. Microbiol

    (2001)
  • L.E. Babiss et al.

    Expression of adenovirus EIA and EIB gene products and the Escherichia coli XGPRT gene in KB cells

    J. Virol

    (1983)
  • C.D. Brandt et al.

    Adenoviruses and paediatric gastroenteritis

    J. Infect. Dis

    (1985)
  • T.W. Burke et al.

    The downstream core promoter element, DPE, is conserved from Drosophila to humans and is recognized by TAFII60 of Drosophila

    Genes Dev

    (1997)
  • S. Chakrabarti et al.

    Community respiratory virus and adenovirus infections in nonmyeloablative transplant recipients conditioned with Campath-1H: High incidence but low mortality

    Blood

    (2001)
  • J.R. Cruz et al.

    Adenovirus types 40 and 41 and rotaviruses associated with diarrhea in children from Guatemala

    J. Clin. Microbiol

    (1990)
  • J.C. de Jong et al.

    Candidate adenoviruses 40 and 41: fastidious adenoviruses from infant stool

    J. Med. Virol

    (1983)
  • J.C. de Jong et al.

    Detection, typing and subtyping of enteric adenoviruses 40 and 41 from faecal samples and observations of changing incidence of infections with these types and subtypes

    J. Clin. Microbiol

    (1993)
  • M.K. Estes et al.

    Rotaviruses: a review

    Curr. Top. Microbiol. Immunol

    (1983)
  • T.H. Flewett et al.

    Epidemic viral enteritis in a long-stay childrens ward

    Lancet

    (1973)
  • P.H. Gallimore et al.

    Adenovirus EIA: remodelling the host cell, a life or death experience

    Oncogene

    (2001)
  • D. Ghosh

    A relational database of transcription factors

    Nucleic Acids Res

    (1990)
  • Cited by (0)

    View full text