Lesional expression of interferon-γ in atopic eczema
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2022, Journal of Investigative DermatologyCitation Excerpt :Examples of diseases belonging to pattern 2 are atopic dermatitis (AD) and other types of eczema; chronic urticaria; and autoimmune bullous diseases such as BP, epidermolysis bullosa acquisita, or herpetiform dermatitis (Eyerich and Eyerich, 2018). In addition to the type 2 immune signature that is present in virtually all forms of AD, type 1 cytokines might be observed in chronic lesions (Grewe et al., 1994; Werfel et al., 1996) and in Th17 signatures preferentially in children (Esaki et al., 2016) and in people with Asian descent (Noda et al., 2015), respectively. As shown before in BP and other autoimmune diseases (Döpp et al., 2000; Sanjuan et al., 2016), IgE-mediated autoimmunity seems to play a key role in the prototype pattern 2 disease AD (Cipriani et al., 2014; Roesner and Werfel, 2019; Tang et al., 2012).
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