X-LINKED ICHTHYOSIS DUE TO STEROID-SULPHATASE DEFICIENCY
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2018, Vitamins and HormonesCitation Excerpt :These compounds have yet to be used in clinical trials of CRPC. It is noteworthy that X-linked ichthyosis is characterized by a loss of STS, raising concerns about the possible long-term adverse side effects of using sulfatase inhibitors for prostate cancer (Alperin & Shapiro, 1997; Webster, France, Shapiro, & Weiss, 1978). The large amount of DHEA-SO4 that remains in the serum even after P450c17 inhibition raises the issue as to whether prostate cancer cells need to synthesize androgens from cholesterol when there is such a significant amount of downstream precursor available.
Role of the liver X receptors in skin physiology: Putative pharmacological targets in human diseases
2017, Chemistry and Physics of LipidsCitation Excerpt :It has been suggested that cholesterol sulfates are important for skin integrity and adhesion of the various layers (Fig. 1). They also act in keratinocyte differentiation by controlling accumulation of proteins involved in the skin barrier, and perturbations in their metabolism are associated ichthyoses (Elias et al., 1984; Epstein et al., 1984; Webster et al., 1978; Williams and Elias, 1981; Williams et al., 1987). Skin has also been described as a “true” steroidogenic organ (Slominski et al., 2014; Thiboutot et al., 2003).
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2017, Journal of Investigative DermatologyNovel indel mutation of STS underlies a new phenotype of self-healing recessive X-linked ichthyosis
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