Research LettersCo-expression of survivin and TERT and risk of tumour-related death in patients with soft-tissue sarcoma
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Cited by (82)
The Multiple Roles of the IAP Super-family in cancer
2020, Pharmacology and TherapeuticsCitation Excerpt :hTERT maintains telomeres and prevents telomere shortening, which normally happens during each cell division,. . A number of reports have correlated Survivin expression with hTERT expression in tumor tissues (Kleinschmidt-DeMasters et al., 2003; Lam, Saleh, Smith, & Ho, 2008; Wellenhofer & Brustmann, 2012; Würl et al., 2002). Moreover, recent reports have shown that Survivin also regulates telomerase activity.
High-Throughput Screening of Myxoid Liposarcoma Cell Lines: Survivin Is Essential for Tumor Growth
2017, Translational OncologyCitation Excerpt :Normally, survivin is expressed during fetal development and also in certain differentiated tissues. High expression of survivin has been found in several malignancies, including sarcomas such as malignant peripheral nerve sheath tumor, pleomorphic liposarcoma, uterine leiomyosarcoma, chondrosarcoma, and Ewing sarcoma [20,39–43]. All primary MLS tumor samples, as well as the three cell lines, showed high nuclear expression of survivin.
Cancer gene expression signatures-The rise and fall?
2013, European Journal of CancerCombination of external beam radiotherapy (EBRT) with intratumoral injection of dendritic cells as neo-adjuvant treatment of high-risk soft tissue sarcoma patients
2012, International Journal of Radiation Oncology Biology PhysicsCitation Excerpt :Survivin is expressed at a high level in many common human cancers but not in normal, terminally differentiated, adult tissues (30, 33). In previous studies the expression of survivin has been evaluated in malignant tissue samples from 63 STS patients as well as from a panel of tumor cell lines (34, 35). High survivin levels were detected in tumor samples from more than 75% of patients with Stage II and from more than 90% patients with Stage III STS (35).
Grading sarcomas: Histologic and molecular approaches
2011, Diagnostic HistopathologyCitation Excerpt :Allowing for these simple rules only few molecular markers could be recognized as prognostic in sarcomas. The history of molecular prognostic markers in sarcomas started in the beginning of the 2000’s, with the study reported by Würl et al.15 The authors showed that expression of two genes TERT (telomerase reverse transcriptase) and survivin (also named BIRC5) is associated to poor outcome in a series of 89 sarcomas of different subtypes. This series was composed of sarcomas with complex genetics such as leiomyosarcomas, pleomorphic rhabdomyosarcomas and pleomorphic liposarcomas, and in these tumours, co-expression of both genes was a significant prognostic factor (P = 0.0004; relative risk 20.1, 95% CI 3.8–106.4).