Levels of Maturation and Reactions to Injury During Neuronal Development

https://doi.org/10.1016/S0079-6123(08)60685-8Get rights and content

Publisher Summary

This chapter discusses the levels of maturation and reactions to injury during neuronal development. The chapter's view, based on experiments with developing neurons, is that the increasing ability of the cells with age to survive axon severance can be closely correlated in time with the cytological maturation of the cell's organelle system for protein synthesis and, therefore, with the cell's competence to maintain itself. It is reasonable to expect that the early stages of organelle evolvement reflect levels of synthetic capacity. More emphasis needs to be placed on this aspect relative to the response to injury. The possible participation of an auto-immune mechanism in aging is not a new concept. The peculiar nature of synthetic levels during neuronal development, however, is suggestive that extraordinary output under cellular stress at certain stages might incite and perpetuate an auto-immune syndrome.

References (59)

  • A.R. Lieberman

    Int. Rev. Neurobiol.

    (1971)
  • B.G. Cragg

    Brain Res.

    (1970)
  • A. LaVelle et al.

    Exp. Neurol.

    (1959)
  • A. Griffith et al.

    Exp. Neurol.

    (1971)
  • D.H. Adams et al.

    Brain Res.

    (1969)
  • P.J. Van Alten et al.

    Exp. Neurol.

    (1966)
  • A. LaVelle et al.

    Exp. Neurol.

    (1969)
  • A. Vulpian

    Arch. Physiol.

    (1868)
  • B.V. Gudden

    Arch. Psychiatr., Berlin

    (1870)
  • P. Weiss et al.

    Anat. Rec.

    (1945)
  • M.C. Prestige

    J. Embryol. Exp. Morphol.

    (1967)
  • T.H. Dunnebacke

    J. Comp. Neurol.

    (1953)
  • A. Hughes et al.

    J. Anat., London

    (1958)
  • W.M. Cowan et al.

    J. Exp. Zool.

    (1967)
  • W.E. Watson

    J. Physiol. London

    (1968)
  • G. Levi

    Arch. Exp. Zellforsch.

    (1925)
  • G. Levi et al.

    J. Exp. Zool.

    (1945)
  • T. Peterfi et al.

    Arch. Exp. Zellforsch.

    (1928)
  • N.T. Spratt

    Introduction to Cell Differentiation

    (1964)
  • V. Hamburger

    Am. Sci.

    (1957)
  • M. Jacobson

    Developmental Neurobiology

    (1970)
  • A LaVelle et al.
  • V.M. Tennyson
  • A. LaVelle et al.

    J. Exp. Zool.

    (1958)
  • A. LaVelle et al.

    Am. J. Anat.

    (1958)
  • A. LaVelle et al.

    Am. J. Anat.

    (1960)
  • A. LaVelle

    Am. J. Anat.

    (1963)
  • A. LaVelle et al.

    Anat. Rec.

    (1970)
  • A. LaVelle J.W. Sechrist, Differences in the retrograde reactions of immature and mature facial neurons of the hamster...
  • Cited by (33)

    • The facial nerve axotomy model

      2004, Brain Research Reviews
    View all citing articles on Scopus
    View full text