Neuroblastoma and the differential diagnosis of small-, round-, blue-cell tumors
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Neuroblastoma: Essential genetic pathways and current therapeutic options
2022, European Journal of PharmacologyCitation Excerpt :The Primary tumor or metastases consist of small round and almost undifferentiated cells gathered as pseudorosettes . Immunohistochemistry (IHC) staining is required to discriminate between neuroblastoma and other round cell tumors such as desmoplastic small round cell tumor, ganglio-neuroblastoma, ganglioneuroma, Ewing's sarcoma (primitive neuroectodermal tumor or PNET), lymphoma, malignant rhabdoid tumor, melanoma, and schwannoma (Finegold et al., 1983). The neuroblasts demonstrate positive immunoreactivity for NSE, S100, CD56, chromogranin, synaptophysin, and vasointestinal peptide (VIP) (Shimada et al., 1999a).
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Ultrastructural Pathology Section, Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20205.
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Department of Pathology, Division of Surgical Pathology, University of North Carolina School of Medicine, Chapel Hill, North Carolina.