Elsevier

Tetrahedron Letters

Volume 39, Issue 21, 21 May 1998, Pages 3609-3612
Tetrahedron Letters

Conversion of carbonimidodithioates into unsymmetrical Di- and Tri- substituted ureas including urea dipeptides

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Abstract

Selective hydrolysis of carbonimidodithioates (3) leads to the thiocarbamates (4), which can be easily transformed to the unsymmetrical ureas (5) by treatment with the appropriate amines. This constitutes a synthesis of ureas without the use of phosgene or carbon monoxide.

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