Incorporation of Cα-methyl amino acids by solid phase peptide synthesis in a peptide sequence

Abstract

(S)-αMethylmethionine, (S)-αMethylleucine, 2-aminoisobutyric acid and (S)-αMethylphenylalanine have been incorporated by solid phase peptide strategy in a peptide sequence. The coupling reactions of these Boc-αMe amino acids and of the following residue in the sequence were readily achieved after silylation with chlorotrimethylsilane of the amine function on the resin.