Terreulactone A, a novel meroterpenoid with anti-acetylcholinesterase activity from Aspergillus terreus
A novel sesquiterpene lactone type meroterpenoid, terreulactone A, was isolated from the solid-state fermentation of Aspergillus terreus and its structure was established by various spectral analysis.
References (10)
- et al.
Lancet
(1976) - et al.
Science
(1982) - et al.
Am. J. Psychiatry
(1982) - et al.
Ann. Neurol.
(1983) - et al.
J. Antibiot.
(2001)
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Aspergillus terreus: Taxonomy, biology, and bioactive secondary metabolites with potential applications
2020, New and Future Developments in Microbial Biotechnology and Bioengineering: Recent Advances in Application of Fungi and Fungal Metabolites: Current AspectsButenolide derivatives from the plant endophytic fungus Aspergillus terreus
2016, FitoterapiaCitation Excerpt :Aspergillus terreus, a common fungus used in chemical and pharmaceutical industry, is well-known for the production of itaconic acid and lovastatin [3]. In the past decades, various kinds of secondary metabolites, such as butenolides, meroterpenoid [4], sesquiterpenes [5], sestertepenoids [6], alkaloids [7], and polyketides [8,9] have been subsequently isolated from terrestrial or marine strains of A. terreus. Particularly, butenolides are considered as typical metabolites in this strain, which exert anticancer [10,11], α-glucosidase inhibitory and antioxidant activity [12,13], antimalarial activity [14], and anti-phytopathogen activity [15].
A new lumazine peptide penilumamide e from the fungus Aspergillus terreus
2016, Natural Product ResearchDrimane-related merosesquiterpenoids, a promising library of metabolites for drug development
2015, Studies in Natural Products ChemistryCitation Excerpt :A new MSRD from the marine fungus Aspergillus versicolor was determined as asperdemin (22) [37]. Pyripyropenes A–R (23–40) are constituents of Aspergillus fumigatus FO-1289 [38–42]. The absolute configuration of pyripyropene A (23) was determined by Mosher NMR spectrum combined with single X-ray diffraction.
Acetylcholinesterase inhibitors as Alzheimer therapy: From nerve toxins to neuroprotection
2013, European Journal of Medicinal ChemistryCitation Excerpt :Terreulactone A (68) and Terreulactone D (69) are meroterpenoid type compounds; with mixed polyketide terpenoid structures that showed AChE inhibition (Table 1). Isoterreulactone A is also a meroterpenoid but contains a seven-membered lactone skeleton in its structure and it is 10 times weaker AChEI than terreulactones [164,165]. These new inhibitors (70, (Table 1)) contain a modified heterocycle which is supposed to interact with the catalytic site and new substituents connected to the nitrogen atom N 20, which is supposed to be responsible for the binding to the peripheral site of the enzyme [166].