Synthesis and biological evaluation of (±)-Z-huperzine A
The synthesis of (±)-Z-huperzine A has been accomplished and the ability of this agent to inhibit acetylcholinesterase has been measured. The compound has an IC50 of 6 x 10−6M, which is comparable to that of huperzine B.
References (7)
- et al.
J. Neurochem.
(1983) - et al.
J. Am. Chem. Soc.
(1989) - A.P. Kozikowski, Y. Xia, E.R. Reddy, I. Hanin, X.C. Tang, J. Med. Chem....
There are more references available in the full text version of this article.
Cited by (18)
Huperzine A from Huperzia species-An ethnopharmacolgical review
2007, Journal of EthnopharmacologyCarinatumins A-C, new alkaloids from Lycopodium carinatum inhibiting acetylcholinesterase
2007, Bioorganic and Medicinal ChemistryThe Lycopodium Alkaloids
2005, Alkaloids: Chemistry and BiologyCitation Excerpt :The dimethyl-carbamoyloxy analogue 232 was synthesized through the keto urethane analogue 231 with a bicyclo[3.3.1]nonane ring (132). The synthesis of (±)-Z-huperzine A (233a), which showed inhibition of AChE comparable to that of huperzine B (2), was accomplished (133). To evaluate the contribution of the ethylidene group, both the methylene analogue 233b and the propylidene analogue 233c were synthesized (117).
Synthesis of an 11-unsubstituted analogue of (±)-huperzine A
1999, Tetrahedron
Copyright © 1990 Published by Elsevier Ltd.