A New Approach to Dihydrobenzofurans and Dihydrobenzopyrans (Chromans) Based on the Intramolecular Trapping by Alcohols of Benzynes Generated from 7-Substituted-1-aminobenzotriazoles
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Optical rotations were measured using an Optical Activity AA-10 polarimeter. Infrared spectra were obtained using a Perkin–Elmer 1720 FTIR spectrometer using liquid films on sodium chloride plates or, if solids, chloroform solutions. 1H NMR spectra were obtained using a Perkin–Elmer R32a instrument operating at 90 MHz (90) or a Bruker WM-250 instrument operating at 250 MHz. 13C NMR spectra were determined using a JEOL EX270 spectrometer operating at 67.8 MHz or the Bruker AM-400 instrument
Acknowledgements
We are most grateful to Dr Robert G. Giles (SB, Tonbridge) for helpful advice, to the EPSRC Mass Spectrometry Centre, University of Wales, Swansea, for the provision of some of the HRMS data and to SB Pharmaceuticals and the EPSRC for financial support through the CASE Scheme.
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