Osteoporosis as a Pediatric Problem

https://doi.org/10.1016/S0031-3955(16)39018-6Get rights and content

Variation in bone mass accumulation during childhood and adolescence is now recognized as an important determinant of the risk of sustaining osteoporotic fractures during adult life; therefore, recent investigations have focussed on the prevention of the disease. Heterogeneity in skeletal development is discussed, and the influence of environmental factors on the attainment of peak bone mass is reviewed.

References (94)

  • J.M. Tanner et al.

    Relative importance of growth hormone and sex steroids for the growth at puberty of trunk length, limb length, and muscle width in growth hormone deficient children

    J Pediatr

    (1976)
  • G.E. Theintz et al.

    Evidence for a reduction of growth potential in adolescent female gymnasts

    J Pediatr

    (1993)
  • P.A. Alffram et al.

    Epidemiology of fractures of the forearm

    J Bone Joint Surg Am

    (1962)
  • R.M. Angus et al.

    Dietary intake and bone mineral density

    Bone Miner

    (1988)
  • R. Armamento-Villareal et al.

    Estrogen status and heredity are major determinants of premenopausal bone mass

    J Clin Invest

    (1992)
  • M.H. Bartley et al.

    The relationship of bone strength and bone quality in health, disease and aging

    J Gerontol

    (1966)
  • J.P. Bonjour et al.

    Inadequate protein intake and osteoporosis: Possible involvement of the IGF system

  • J.P. Bonjour et al.

    Critical years and stages of puberty for spinal and femoral bone mass accumulation during adolescence

    J Clin Endocrinol Metab

    (1991)
  • J.P. Bonjour et al.

    Peak bone mass

    Osteoporos Int

    (1994)
  • M. Calvo et al.

    Persistently elevated parathyroid hormone secretion and action in young women after four weeks of ingesting high phosphorus, low calcium diets

    J Clin Endocrinol Metab

    (1990)
  • N. Cameron et al.

    A longitudinal analysis of the growth of limb segments in adolescence

    Ann Hum Biol

    (1982)
  • M.D. Carroll et al.

    Dietary intake source data: United States 1976–1980

    Vital Health Stat

    (1983)
  • C. Christiansen

    Bone mineral measurement with special reference to precision, accuracy, normal values, and clinical relevance

  • Consensus Development Conference: Diagnosis, prophylaxis and treatment of osteoporosis

    Am J Med

    (1991)
  • S.R. Cummings et al.

    Appendicular bone density and age predict hip fractures in women

    JAMA

    (1990)
  • S.R. Cummings et al.

    Epidemiology of osteoporosis and osteoporotic fractures

    Epidemiol Rev

    (1985)
  • H. De Boer et al.

    Consequences of childhood-onset growth hormone deficiency for adult bone mass

    J Bone Miner Res

    (1994)
  • S. Dhuper et al.

    Effects of hormonal status on bone density in adolescent girls

    J Clin Endocrinol Metab

    (1990)
  • M.S. Dunnil et al.

    Quantitative histological studies on age changes in bones

    J Pathol Bacteriol

    (1967)
  • K.G. Faulkner et al.

    Simple measurement of femoral geometry predicts hip fracture: The study of osteoporotic fractures

    J Bone Miner Res

    (1993)
  • R.A. Faulkner et al.

    Regional and total bone mineral content, bone mineral density, and total body tissue composition in children 8–16 years of age

    Calcif Tissue Int

    (1993)
  • P. Gardsell et al.

    The predictive value of bone loss for fragilities fracture in women: A longitudinal study over 15 years

    Calcif Tissue Int

    (1991)
  • S. Gam

    The earlier gain and the later loss of cortical bone in nutritional perspective

    (1970)
  • V. Gilsanz et al.

    Peak trabecular vertebral density: A comparison of adolescent and adult females

    Calcif Tissue Int

    (1988)
  • V. Gilsanz et al.

    Vertebral bone density in children: Effect of puberty

    Radiology

    (1988)
  • V. Gilsanz et al.

    Changes in vertebral bone density in black girls and white girls during childhood and puberty

    N Engl J Med

    (1991)
  • C. Glastre et al.

    Measurement of bone mineral content of the lumbar spine by dual energy x-ray absorptiometry in normal children: Correlations with growth parameters

    J Clin Endocrinol Metab

    (1990)
  • C.L. Gordon et al.

    The contributions of growth and puberty to peak bone mass

    Growth Dev Aging

    (1991)
  • P. Gueusens et al.

    Age-, sex- and menopause-related changes of vertebral and peripheral bone: Population study using dual and single photon absorptiometry and radiogrammetry

    J Nucl Med

    (1986)
  • H. Hagino et al.

    Fracture incidence and bone mineral density of the distal radius in Japanese children

    Arch Orthop Trauma Surg

    (1990)
  • L. Halouia et al.

    Lifetime calcium intake and physical activity habits: Independent and combined effects on the radial bone of health premenopausal Caucasian women

    Am J Clin Nutr

    (1989)
  • P.J. Hay et al.

    Predictors of osteopenia in women with anorexia nervosa

    Calcif Tissue Int

    (1992)
  • W.C. Hayes et al.

    Biomechanics of bone: Applications of assessment of bone strength

  • R.P. Heaney

    Lifelong calcium intake and prevention of bone fragility in the aged

    Calcif Tissue Int

    (1991)
  • T.L. Holbrook et al.

    Dietary calcium and risk of hip fracture: A 14 year prospective population study

    Lancet

    (1988)
  • A. Horsman et al.

    Estimation of mechanical properties of the distal radius from bone mineral content and cortical width

    Clin Orthop

    (1983)
  • S.L. Hui et al.

    Bone mass in normal children and young adults

    Growth

    (1985)

    • Cited by (101)

    • Growth of cortical bone thickness and trabecular bone density in Japanese children

      2020, Bone
      Citation Excerpt :

      The acquisition of a high bone density at an early age is important to delay the onset of osteoporosis and to avoid reaching the fracture threshold due to age-related reductions in bone density [2]. Previous studies have reported that bone density increased between 1 and 4 years of age, and between 12 and 17 years of age, with growth spurts being observed in adolescence [3,4]. There are reports on the bone density of children using ultrasonography [5,6], and peripheral quantitative computed tomography (pQCT) [7,8].

    • Maximal Oxygen Consumption and Bone Mass in French boys

      2015, Journal of Clinical Densitometry

    • The IL6 gene polymorphism -634C>G and IL17F gene polymorphism 7488T>C influence bone mineral density in young and elderly Japanese women

      2012, Gene
      Citation Excerpt :

      The BMD% of YAM was < 100% in 41% of the young women. Considering that the risk of postmenopausal osteoporosis depends on the rate of bone loss and on peak bone mass (Bachrach, 2001; Carrié Fässler and Bonjour, 1995; Ilich et al., 1996), these statistics imply that these women are at high risk of developing osteoporosis in the future. When comparing BMD by polymorphisms in each population, we used the actual BMD value for young women, and the adj-BMD value for elderly women, because of the wide ranges of age and BMI in the elderly women.

    • Of small bones and big mistakes; bone densitometry in children revisited

      2009, European Journal of Radiology
      Citation Excerpt :

      Paediatricians, and others involved in children's health care, might consider ‘how does this concern me?’ However, in 1973 Professor Charles Dent originally postulated that ‘senile osteoporosis is a paediatric disease’ and this concept has been subsequently supported by others [2–7]. The importance of achieving maximum peak bone mass (PBM), i.e. the highest bone mineral density (BMD) achieved in young adulthood, is recognised as an important factor in the prevention of osteoporosis in later life.

    • Effect of micronutrient supplement on health and nutritional status of schoolchildren: Bone health and body composition

      2006, Nutrition

    • The association between dietary protein intake and bone mass accretion in pubertal girls with low calcium intakes

      2010, British Journal of Nutrition
    View all citing articles on Scopus

    Address reprint requests to: Anne-Lise Carrié Fässler, PhD, Department of Nutrition, Nestec Ltd., Nestlé Research Center, Vers-chez-les-Blanc, Route du Jorat, CH-1000 Lausanne 26, Switzerland

    View full text
    Copyright © 1995 Elsevier Inc. All rights reserved.