Differential impairments in recalling people's names: A case study in search of neuroanatomical correlates
Introduction
Evidence from a number of sources including positron-emission-tomographic studies 18, 26, 35, 36, 42, 58and single case reports 12, 13, 14, 50makes it likely that circumscribed cortical regions represent specific semantic attributes. After certain kinds of brain damage patients may no longer be able to name and describe living objects such as a snake or a crocodile, while they are still able to name and describe objects like a tent or a compass 11, 61. A special class of semantic termini is defined by proper names and—as a specific subset—by people's names, and may be selectively impaired by cortical damage 5, 25, 30, 37, 46, 47, 48, 49.
Possibly dependent on specific features of the impairment in name reproduction, left thalamic 6, 30, 39, left temporal 22, 37, 49, left parieto-occipital [47]and left-hemispheric fronto-temporal damage 25, 48have been found to result in impairment for proper names. While lesion data are divergent, Damasio and colleagues [9]conducted word-retrieval experiments with both brain damaged patients and normal subjects undergoing positron-emission-tomography (PET). For both groups of subjects, retrieval of words signifying concrete entities (names for persons, animals, tools) depended on different regions of the temporal lobe, whereas naming actions activated the left frontal cortex. In a study likewise based on PET data, Martin et al. [36]found that naming pictures of animals was associated with bilateral activations of the ventral temporal lobe, Broca's area and the medial occipital lobe.
With regard to the nature of the deficit, anomia may or may not be embedded in the context of more widespread amnesia. Based on different assumptions, numerous authors have suggested that anomia for proper names constitutes a retrieval deficit 15, 22, or, more specifically, an inability to form—for retrieval—new associations between the meanings of words and their phonological forms [49].
Several further findings have helped to clarify the cognitive aspects involved in naming people. Flude and colleagues [17]assumed that names are stored separately from semantic information about people, and Damasio et al. [9]even hypothesized segregated neural systems subserving conceptual and word-form knowledge for the same stimulus. From experimental studies with normal subjects, Valentine et al. [57]concluded that name recognition units mediating between word recognition and the access to identity-specific semantics exist. Similarly, Fery and colleagues [15]presumed that anomia is caused by an impaired access to intact phonological representations from semantic memory. On the other hand, as there is evidence that names (e.g. `Baker') with name–occupation homophones are more difficult to recall than occupations (e.g. baker) [38], this disadvantage for proper names cannot be attributed to differences in the phonological word-form [7], but has to be discussed in the context of word meaning. Indeed, proper names seem to be unique because of their low meaningfulness; they therefore work as `pure referring expressions' [48]without describing any properties or attributes of the corresponding persons [25]. Moreover, Burton and Bruce [4]emphasized the uniqueness of a name to a given person. A survey of current models and a discussion of recent cases can be found in Cohen and Burke [8].
We here report a new case of a selective anomia for people's names focusing on its neuronal correlates and on the nature of the distinct impairments of different memory systems.
Section snippets
Case report
CU is a 61-year-old, right-handed, female music teacher who came to our attention with conspicious problems in remembering names. Following 10 days of indisposition, symptom-onset on 10 December 1995 presented with a bad left-sided headache, nominal aphasia and transient confusion.
She suffered an ischaemic/embolic (?) insult in the left medial temporal lobe probably caused by an atrial septum aneurysm. Acute computer tomographic and magnetic resonance imaging (MRI) scans showed an oedema zone
Discussion
We have described a patient with a quite selective—category-specific—anomia for people's names, who was nearly perfect in naming pictures or generating common and proper names of other semantic categories. When the words belong to categories of common names (for example, clothes) as well as proper ones (such as cities), results just below average can be due to a continuing slight general anomia rather than selectively account for another special type of anomic disturbance. Furthermore, the
Acknowledgements
We thank the patient and her mother for their cooperation in all testing procedures. We also thank Ralf Babinsky for fruitful comments and David Emmans for improvement of the English text. Research was supported by the German Research Council (grant Ma 795/15-2).
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2022, Handbook of Clinical NeurologyCitation Excerpt :In a few cases, the disturbance extended to the receptive side, with an inability to comprehend the name (Verstichel et al., 1996; Busigny et al., 2015). In a proper-name anomia case with selective medial and lateral left temporal lobe damage (Reinkemeier et al., 1997), learning of face-name associations was preserved and was independent of the ability to generate context-specific information for the subjects whose names were requested. All these cases critically contributed to the interest raised by the comparison of the mechanisms involved in the retrieval and semantic storage of proper names and common nouns.
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2020, NeuroscienceCitation Excerpt :A growing body of evidence supports the role of this structure in proper naming. Specifically, a decrease in proper naming has been found in left ATL damage (Grabowski et al., 2001; Glosser et al., 2003; Drane et al., 2008; Benke et al., 2013) due to different aetiologies (Lucchelli and De Renzi, 1992; Verstichel et al., 1996; Reinkemeier et al., 1997; Papagno and Capitani, 1998; Saetti et al., 1999; Miceli et al., 2000; Giussani et al., 2009; Papagno et al., 2018). Critically, what seems to be crucial is the integrity of the uncinate fasciculus, a white matter tract linking the anterior temporal lobe with the inferior frontal gyrus (Papagno et al., 2011, 2016).
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2015, CortexCitation Excerpt :The reverse dissociation, common noun anomia without proper name anomia, was also described, providing evidence of a double dissociation between common and proper name retrieval (Lyons, Hanley, & Kay, 2002; Martins & Farrajota, 2007). While proper name anomia generally involves people's names and other proper names, some rare cases demonstrated that people's names can be affected selectively, in the absence of impairment in naming places (e.g., Carney & Temple, 1993; Cohen, Bolgert, Timsit, & Chermann, 1994; Fery et al., 1995; Lucchelli, Muggia, & Spinnler, 1997; Reinkemeier, Markowitsch, Rauch, & Kessler, 1997; Verstichel, Cohen, & Crochet, 1996), monuments (Fery et al., 1995; Lucchelli et al., 1997; Verstichel et al., 1996) or brands (Lucchelli et al., 1997). However, Hanley and Kay (1998) suggested that the extension of the impairment to other proper name categories correlates with its severity and that selective people's names' anomia is observed only in the less severe cases.
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2015, NeuropsychologiaCitation Excerpt :Indeed, the tip of the tongue state (TOT), a feeling of familiarity with an item coupled with the inability to retrieve its corresponding name, is significantly more evident for proper than common names in the aging population (Evrard, 2002, but see Ramscar et al. (2014), for a different perspective on cognitive decline with aging). Damage to the left anterior temporal lobe (ATL) has been associated with proper name retrieval deficits (Damasio et al., 1996; Tranel et al., 1997; Lucchelli and De Renzi, 1992; Verstichel et al., 1996; Reinkemeier et al., 1997; Saetti et al., 1999). However, Semenza (2011) has argued that while clinical group studies support the idea that proper name recollection takes place in the left ATL, case studies of selective proper name anomia or sparing and neuroimaging studies, suggest the involvement of a larger network.
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2009, Neuropsychologia