Elsevier

Journal of Aerosol Science

Volume 29, Supplement 2, September 1998, Pages S1271-S1272
Journal of Aerosol Science

Supercritical CO2-assisted methods for the production and pulmonary administration of pharmaceutical aerosols

https://doi.org/10.1016/S0021-8502(98)90818-7Get rights and content

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    Briefly, the depressurization of a liquid together with a supercritical fluid (at high pressure) enhances the liquid jet breakup into sub-micrometric droplets. The use of the supercritical enhanced atomization properties was first described as the CO2-assisted nebulization with a bubble dryer (CAN-BD) [16–18]. However, many variants have emerged with different nozzle design [19].

  • Experimental investigation and modeling of the solubility of carvedilol in supercritical carbon dioxide

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    Due to these concerns, scientists attempt to utilize the supercritical fluid technology in this area. So recently, application of supercritical fluid technologies especially has been increasingly examined for micronization which a complete review of this application has been performed by Türk [4], emulsions and micro-emulsions [5], solid dispersions [6], drug delivery [7], etc. The main parameter is necessary for successful application of supercritical fluid-based technologies in the pharmaceutical industry is the knowledge of solubility of substances in the different operational conditions.

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    2013, Journal of Supercritical Fluids
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    In the light of the mild critical conditions and its other desired characteristics supercritical carbon dioxide (SC-CO2) is widely used in pharmaceutical processing. In detail, during the past decades, several researchers have investigated the potential of supercritical fluids for different applicable scenario of supercritical fluids for pharmaceutical processing and particle engineering [4–15]. Whether a supercritical fluid is being used as an extraction solvent or as a reaction medium or micron or nano particles producer, the ability to obtain the solubility of compounds in the supercritical fluid is crucial in determining proper operating conditions.

  • Development of a novel mucosal vaccine against strangles by supercritical enhanced atomization spray-drying of Streptococcus equi extracts and evaluation in a mouse model

    2012, European Journal of Pharmaceutics and Biopharmaceutics
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    The significant pressure drop, together with the burst of the dissolved gas, causes the formation of microdroplets and microbubbles, described as an effervescent atomization [19]. This supercritical enhanced atomization was first developed and registered as the CO2-Assisted Nebulization with a Bubble Dryer (CAN-BD®) [19,21,22]. Several variants exist, each with its distinct design (reviewed elsewhere [20]), some of which are also under intellectual property protection [23].

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