ReviewSimian virus 40 in human cancers☆
Section snippets
Literature search
We used MEDLINE to search the medical literature (through October 2002) for original studies of polyomavirus SV40 and human cancers. We used combinations of key words, including SV40 and cancers, SV40 and brain cancers, SV40 and malignant mesothelioma, SV40 and bone cancers, SV40 and lymphomas, and SV40 and non-Hodgkin’s lymphoma. The computer search was supplemented by consulting the bibliographies from retrieved articles.
Inclusion and exclusion criteria
Only full-length, original articles were considered for inclusion.
Results
The search yielded 66 original articles 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82; 22 studies were eliminated because they did not include a control group or included only one control sample 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72,
Discussion
We found a significant excess risk of polyomavirus SV40 associated with human primary brain tumors, malignant mesotheliomas, bone cancers, and non-Hodgkin’s lymphoma, as compared with control samples. These types of human cancers associated with SV40 are the same as those induced by SV40 in animal models. Although the proportion of cancers containing SV40 varied among studies, viral prevalence was always far greater in primary tumors than in control tissues. In addition to the detection of SV40
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Simian virus 40-like DNA sequences in human pleural mesothelioma
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Molecular biology studies on mesothelioma tumor samplespreliminary data on H-ras, p21, and SV40
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Simian virus 40 large T antigen (SV40LTAg) primer specific DNA amplification in human pleural mesothelioma tissue
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SV40 expression in human neoplastic and non-neoplastic tissuesperspectives on diagnosis, prognosis and therapy of human malignant mesothelioma
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Detection of SV40 sequences in human mesothelioma
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Presence of simian virus 40 sequences in malignant pleural, peritoneal and noninvasive mesotheliomas
Int J Cancer
Detection of SV40 like viral DNA and viral antigens in malignant pleural mesothelioma
Eur Respir J
SV40 large T-antigen and human pleural mesotheliomascreening by polymerase chain reaction and tyramine-amplified immunohistochemistry
Virchows Arch
SV40, JC and BK expression in tissue, urine and blood samples from patients with malignant and nonmalignant pleural disease
Anticancer Res
Simian virus-40 sequences are a negative prognostic cofactor in patients with malignant pleural mesothelioma
Genes Chromosomes Cancer
Simian virus 40 is not a cofactor in the pathogenesis of environmentally induced malignant pleural mesothelioma in Turkey
Anticancer Res
A multicenter evaluation of assays for detection of SV40 DNA and results in masked mesothelioma specimens
Cancer Epidemiol Biomarkers Preven
Aberrant methylation and simian virus 40 Tag sequences in malignant mesothelioma
Cancer Res
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This study was supported in part by the Baylor Center for AIDS Research Core Support Grant AI36211 from the National Institute of Allergy and Infectious Diseases, Bethesda, Maryland. Dr. Vilchez is the recipient of the 2001 Junior Faculty Development Award from GlaxoSmithKline, Philadelphia, Pennsylvania, and the 2002 Translational Research Award from the Leukemia & Lymphoma Society, White Plains, New York. The funding sources had no role in study design; the collection, analysis, or interpretation of data; and the preparation, review, or approval of the manuscript.