The use of positron emission tomography in the clinical assessment of dementia*
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Cited by (95)
Positron Emission Tomography-Based Assessment of Cognitive Impairment and Dementias, Critical Role of Fluorodeoxyglucose in such Settings
2022, PET ClinicsCitation Excerpt :A large number of foundational studies show that this pattern of temporo-parietal hypometabolism has a sensitivity of approximately 85% to 90%, a specificity of approximately 60% to 70%, and a negative predictive value ranging from 77% to 95% in screening for AD.16 However, because this pattern can be observed in patients with other conditions including Parkinson disease, DLB, bilateral parietal stroke, bilateral parietal subdural hematomas, and bilateral parietal radiation therapy ports, it is not considered to be pathognomonic for AD.17 Furthermore, recent findings suggest that other patterns of hypometabolism, such as that within the entorhinal cortex, may be more specific to AD and thus provide more accurate diagnostic biomarkers of AD.18
Cognitive Impairment and Dementias
2018, Seminars in Nuclear MedicineCitation Excerpt :Based on a large number of studies, this temporo-parietal hypometabolism pattern has a sensitivity of approximately 85%-90% and specificity of approximately 60%-70%. However, the pattern is not pathognomonic for AD since it can be observed in patients with other conditions including Parkinson's disease, bilateral parietal stroke, bilateral parietal subdural hematomas, and bilateral parietal radiation therapy ports.17 In reviewing the extant data from resting FDG-PET studies, regional glucose hypometabolism is a prominent indicator of disease in AD patients.
Fluorodeoxyglucose positron emission tomography/magnetic resonance imaging: Current status, future aspects
2014, PET ClinicsCitation Excerpt :Although high physiologic uptake can limit FDG cerebral PET value, there is much ongoing research with newer PET tracers. Neurodegenerative disorders such as Alzheimer dementia (AD) affect a large percentage of the aging population.66 The dementia spectrum includes several different dementias with distinct clinical features and treatments.
Investigation of Nonneoplastic Neurologic Disorders with PET and MRI
2008, PET ClinicsNeuroimaging and Human Genetics
2005, International Review of NeurobiologyCitation Excerpt :Alzheimer's disease (AD) is a complex polygenic disorder in most cases (Emahazion et al., 2001; Farrer et al., 1991) and is the most common form of dementia in adults, affecting approximately 7% of people older than 65 and perhaps 40% of people older than 80 (Price, 2000). The disease is typically characterized by a severe decline in memory performance (American Psychiatric Association, 1995), and from an imaging perspective, slowing of resting EEG in the temporoparietal region (Dierks et al., 1991; Duffy et al., 1984), prolonged latency (and amplitude reduction) of the temporoparietal P300 event‐related potential component (Brown et al., 1983; Syndulko et al., 1982), volume reduction of the medial temporal lobe in MRI or CT scans (Jack et al., 1992; Jobst et al., 1992; Scheltens et al., 1992), a decline of white and gray matter tissue anisotropy that is most prominent in the temporal lobe (Bozalli et al., 2001), and decreased parietotemporal regional blood flow and glucose‐uptake in PET and SPECT scans (Benson et al., 1981; Herholz et al., 2002a,b; Mazziotta et al., 1992). To some extent, comparable, but more subtle, abnormalities are also observed in subjects at familial risk for the disease (Boutros et al., 1995; Burggren et al., 2002; Green and Levey, 1999; Ponomareva et al., 1998) or in early stages of the illness (De Santi et al., 2001; Fellgiebel et al., 2004; Grundmann et al., 2002; Huang et al., 2000; Killiany et al., 2002).
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Supported in part by grants from the National Institute of Neurological Disease and Stroke (NS-15654, NS-20867), Biomedical Research (447145-MP24188), UCLA School of Medicine (USHHS RR5354), and the National Institute of Mental Health (MH-37916), and a contract from the Department of Energy (#DE-AC03-SF-7600012)