Synthesis of 6-substituted 5-cyano-7-hydroxy-2-carboxybenzofurans

doi:10.1016/j.tetlet.2010.07.020

Tetrahedron Letters

Volume 51, Issue 36, 8 September 2010, Pages 4720-4722

https://doi.org/10.1016/j.tetlet.2010.07.020 Get rights and content

Abstract

Methods for the synthesis of 5-cyano-7-hydroxy-2-carboxybenzofurans bearing a variety of substituents at the 6-position are outlined. The scope and limitations of lithiation processes, electrophilic substitutions, and pericyclic reactions are investigated.

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Synthesis of 6-substituted 5-cyano-7-hydroxy-2-carboxybenzofurans

Abstract

Graphical abstract

Pharmacol. Ther.

Expert Opin. Ther. Patents

J. Org. Chem.

J. Org. Chem.