Unexpected one-pot synthesis of new polycyclic coumarin[4,3-c]pyridine derivatives via a tandem hetero-Diels–Alder and 1,3-dipolar cycloaddition reaction
Graphical abstract
O-Methyl-4-coumarincarboxaldehyde oxime reacted with electron-deficient and electron-rich dienophiles to give, in one step, coumarin[4,3-c]pyridine derivatives. The regio- and stereoselectivities of the new compounds correspond well with spectroscopic and theoretical data. A possible mechanistic scheme is provided.
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Acknowledgments
D.R. Gautam thanks State Scholarships Foundation (IKY), Greece, for financial support and Tribhuvan University, Katmandu, Nepal, for granting him the PhD study leave.
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