Significant rate acceleration of the aza-Michael reaction in water

doi:10.1016/j.tetlet.2006.10.142

Tetrahedron Letters

Volume 48, Issue 1, 1 January 2007, Pages 141-143

https://doi.org/10.1016/j.tetlet.2006.10.142 Get rights and content

Abstract

The addition of amines to conjugated alkenes has been carried out in water at room temperature very efficiently without any catalyst. Significant rate acceleration of this reaction is observed in water compared to organic solvents.

Graphical abstract

Remarkable rate acceleration is reported for the aza-Michael reaction in water at room temperature in the absence of any catalyst or co-organic solvent.

Section snippets

Acknowledgements

We are pleased to acknowledge the financial support from CSIR [Grant No. 01(1936)/04/EMR-1]. S.B. also thanks CSIR for his fellowship.

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Citation Excerpt :
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Significant rate acceleration of the aza-Michael reaction in water

Abstract

Graphical abstract

Section snippets

Acknowledgements

J. Am. Chem. Soc.

Tetrahedron Lett.

Org. Lett.

J. Org. Chem.

Org. Lett.

J. Org. Chem.

J. Am. Chem. Soc.

Chem. Soc. Rev.

J. Am. Chem. Soc.