Elsevier

Tetrahedron Letters

Volume 47, Issue 45, 6 November 2006, Pages 7853-7856
Tetrahedron Letters

Addition of carbon nucleophiles to cyclic N-acyliminium and oxocarbenium ions under solvent-free conditions

https://doi.org/10.1016/j.tetlet.2006.09.023Get rights and content

Abstract

The InCl3-catalyzed addition of carbon nucleophiles to cyclic N-acyliminium and oxocarbenium ions under solvent-free conditions at room temperature is described. The corresponding α-substituted heterocycles were obtained in moderate to excellent yields.

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Acknowledgements

The authors would like to thank FAPESP (Fundação de Amparo à Pesquisa no Estado de São Paulo) for the financial support and fellowship and CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico) for the research fellowship.

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