Highly regioselective Friedel–Crafts alkylation of indoles with α,β-unsaturated N-acylbenzotriazoles
Graphical abstract
The Friedel–Crafts alkylation rather than acylation of indoles was realized with α,β-unsaturated N-acylbenzotriazoles catalyzed by samarium(III) iodide under reflux in dry THF. The reaction was highly regioselective, and a series of new 3-substituted indole derivatives were obtained and could be further transformed into various indole derivatives due to the presence of active acylbenzotriazole moiety.
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Acknowledgement
We are grateful to Zhejiang Provincial Natural Science Foundation of China (Project No. Y405035) for financial support.
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