Microwave-assisted efficient, one-pot, three-component synthesis of 3,5-disubstituted 1,2,4-oxadiazoles under solvent-free conditions

doi:10.1016/j.tetlet.2006.02.102

Tetrahedron Letters

Volume 47, Issue 17, 24 April 2006, Pages 2965-2967

https://doi.org/10.1016/j.tetlet.2006.02.102 Get rights and content

Abstract

A novel synthesis of 1,2,4-oxadiazoles is described from a one-pot, three-component reaction between nitriles, hydroxylamine, and aldehydes under microwave irradiation and solvent-free conditions in excellent yields.

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Acknowledgement

This research was supported by the Research Council of the University of Tehran as research project (6102036/1/02).

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Microwave-assisted efficient, one-pot, three-component synthesis of 3,5-disubstituted 1,2,4-oxadiazoles under solvent-free conditions

Abstract

Graphical abstract

Section snippets

Acknowledgement

Chem. Ber.

Helv. Chim. Acta

Adv. Heterocycl. Chem.

J. Med. Chem.

Bioorg. Med. Chem. Lett.