Elsevier

Tetrahedron Letters

Volume 46, Issue 19, 9 May 2005, Pages 3279-3282
Tetrahedron Letters

Highly efficient KF/Al2O3-catalyzed versatile hetero-Michael addition of nitrogen, oxygen, and sulfur nucleophiles to α,β-ethylenic compounds

https://doi.org/10.1016/j.tetlet.2005.03.112Get rights and content

Abstract

The first example of KF/Al2O3-catalyzed versatile hetero-Michael addition reaction of nitrogen, oxygen, and sulfur nucleophiles was developed for facile preparation of organic compounds of widely different structures. In contrast with the existing methods using many acidic catalysts, this method is very general, simple, high-yielding, environmentally friendly, and oxygen and moisture tolerant.

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Acknowledgements

The study was financially supported by the Natural Science Founder of China (No. 20402017).

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