Elsevier

Tetrahedron Letters

Volume 45, Issue 28, 5 July 2004, Pages 5469-5471
Tetrahedron Letters

The first total synthesis of SB87-Cl and pestalone, novel bioactive benzophenone natural products

https://doi.org/10.1016/j.tetlet.2004.05.063Get rights and content

Abstract

SB87-Cl 1, an inhibitor of testosterone-5α-reductase, and pestalone 2 exhibiting effective antimicrobial activity against MRSA (MIC = 37 ng/mL) and VRE (MIC = 78 ng/mL), were novel bioactive benzophenone natural products. Total synthesis of 1 and 2 has been successfully accomplished. The common synthetic precursor 18 of 1 and 2, was successfully obtained by the coupling of 8 with 12.

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Acknowledgements

This work was supported by Grant-in-Aid for the 21st Century COE program `Keio Life Conjugate Chemistry', as well as Scientific Research C from the Ministry of Education, Culture, Sports, Science, and Technology, Japan.

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