Elsevier

Tetrahedron Letters

Volume 44, Issue 51, 15 December 2003, Pages 9177-9180
Tetrahedron Letters

A new route to acyclic nucleosides via palladium-mediated allylic alkylation and cross-metathesis

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Abstract

A method for the syntheses of E-unsaturated acyclic nucleosides via a combination of palladium-catalyzed allylic alkylation and ruthenium-based cross metathesis is described. This approach provides a concise, efficient and reliable route to new nucleoside analogues.

An efficient and useful method for the syntheses of acyclic nucleosides via a combination of palladium-catalyzed allylic alkylation and ruthenium-based cross metathesis is described. This approach provides a concise, efficient and reliable route to new nucleoside analogues.

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Acknowledgements

We thank the CNRS and MENRT for financial support. F. Amblard thanks the MENRT for a Ph.D. fellowship. Work performed at the University of New Orleans was supported by the National Science Foundation.

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