Magnetic vectoring of magnetically responsive nanoparticles within the murine peritoneum

doi:10.1016/j.jmmm.2006.10.1163

Journal of Magnetism and Magnetic Materials

Volume 311, Issue 1, April 2007, Pages 330-335

https://doi.org/10.1016/j.jmmm.2006.10.1163 Get rights and content

Abstract

Magnetically responsive nanoparticles (MNPs) might be candidates for pro-drug formulations for intraperitoneal (i.p.) treatment of ovarian cancer. We conducted feasibility experiments in an i.p. human ovarian carcinoma xenograft model to determine whether MNPs can be effectively vectored within this environment. Our initial results based on magnetic resonance imaging (MRI) indicate that i.p.-injected ∼15 nm magnetite-based MNPs can in fact migrate toward NdFeB magnets externally juxtaposed to the peritoneal cavity above the xenografts growing in the anterior abdominal wall. MNP localization to the tumor/peri-tumoral environment occurs. Further development of this MNP pro-drug strategy is underway.

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Journal of Magnetism and Magnetic Materials

Magnetic vectoring of magnetically responsive nanoparticles within the murine peritoneum

Abstract

Best Pract. Res. Clin. Obstet. Gynaecol.

Eur. J. Surg. Oncol.

J. Surg. Res.

Biomaterials

J. Control Rel.

Clin. J. Oncol. Nurs.

J. Br. Menopause Soc.

Int. J. Gynecol. Cancer.

BMC Cancer

J. Clin. Oncol.

Future Oncol.

Int. J. Gynecol. Cancer

Magnetic nanovectors for drug delivery

Magnetic nanovectors for drug delivery

Magnetic colloids as drug vehicles

Advancements and new technologies in drug delivery system

Anti-tumor activity of drug-loaded magnetic nanoparticles

Nanomaterials for Medical Applications