J Appl Biomed 15:161-168, 2017 | DOI: 10.1016/j.jab.2017.03.002

Hits and defeats of genome-wide association studies of atopy and asthma

Hanna Danielewicz*
Wroclaw Medical University, 1st Department and Clinic of Pediatrics, Allergology and Cardiology, Wroclaw, Poland

Atopy and asthma are complex conditions, recognised as outcomes in which both genes and environment play crucial role. Large number of disease associated loci have been identified within GWAS approach over last years and the knowledge of pathobiology of asthma and allergy has widened substantially. However still the results achieved are difficult to interpret. Most markers have no clear function on and expound small portion of heritability. The "missed heritability" could be hidden in the gene-by environment interactions. The most know environmental factor which interacts with asthma and atopy is farming. The common link between genes and environment could be epigenetics.

Keywords: GWAS; Asthma; Atopy; Gene-environment; Epigenetics; Farming

Received: November 16, 2016; Revised: March 7, 2017; Accepted: March 7, 2017; Published: July 1, 2017  Show citation

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Danielewicz H. Hits and defeats of genome-wide association studies of atopy and asthma. J Appl Biomed. 2017;15(3):161-168. doi: 10.1016/j.jab.2017.03.002.
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