Original contributionsAnalysis of α-methylacyl-CoA racemase (P504S) expression in high-grade prostatic intraepithelial neoplasia
Section snippets
Case selection
High-grade PIN was defined as the presence of neoplastic cells with significant nuclear atypia within preexisting prostatic glands (ducts and acini). A total of 140 cases of high-grade PIN present in prostatectomy specimens were randomly selected from 3 participating hospitals. Prostatectomies were performed for the treatment of prostatic adenocarcinoma in 130 cases (radical prostatectomy), bladder urothelial carcinoma in 5 cases (cystoprostatectomy), or benign prostatic hyperplasia in 5 cases
AMACR/P504S expression in high-grade PIN
The diagnosis of high-grade PIN was confirmed by the presence of basal cells positive for 34βE12 in all 140 cases. AMACR/P504S immunoreactivity was detected in 126 of the 140 cases (90.0%) of high-grade PIN that were included in the study (Table 2). However, not all high-grade PIN glands were positive for AMACR/P504S. Of the 3954 prostatic glands involved by high-grade PIN in these 140 cases, 1642 glands (41.5%) were positive for AMACR/P504S. Furthermore, high-grade PIN had weaker staining
Discussion
In recent years, there has been an increasing interest in identifying precursor lesions of prostate cancer. The most promising candidate to date is high-grade PIN. The original observation suggesting this association was made by McNeal and Bostwick2 in prostates in which a high percentage of PIN co-existed with prostatic adenocarcinoma. Since then, additional supporting biological and biochemical evidence has been obtained.13, 14, 15, 16, 17 Pathological diagnosis of high-grade PIN is
Acknowledgements
The authors thank Dr Borko Jovanovich, Department of Preventive Medicine, Northwestern University, Feinberg School of Medicine for statistical analysis.
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CDK19 as a diagnostic marker for high-grade prostatic intraepithelial neoplasia
2021, Human PathologyCitation Excerpt :However, the frequency of these alterations in HGPIN is low and they do not occur recurrently thus they are not suitable as diagnostic markers for HGPIN. The most routinely used diagnostic biomarkers distinguishing PCa from benign mimickers is AMACR which has also been reported to be expressed in HGPIN [27,28]. The combined detection of AMACR expression and Annexin II loss in prostatic glands has been suggested to support the diagnosis of HGPIN [29]; however, their expression in HGPIN is heterogenous and their application as biomarkers has not been established yet.
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