Identification of Intrinsic Imaging Phenotypes for Breast Cancer Tumors: Preliminary Associations with Gene Expression Profiles: Ashraf AB, Daye D, Gavenonis S, et al (Univ of Pennsylvania Perelman School of Medicine, Philadelphia) Radiology 272:374-384, 2014§

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Purpose

To present a method for identifying intrinsic imaging phenotypes in breast cancer tumors and to investigate their association with prognostic gene expression profiles.

Materials and Methods

The authors retrospectively analyzed dynamic contrast material-enhanced (DCE) magnetic resonance (MR) images of the breast in 56 women (mean age, 55.6 years; age range, 37–74 years) diagnosed with estrogen receptor-positive breast cancer between 2005 and 2010. The study was approved by the institutional review board and compliant

Commentary

Breast cancer is no longer regarded as a single entity; instead, it represents a group of heterogeneous subtypes classified at a molecular level, as shown in earlier work by Sørlie and colleagues.1 A recurrence score is derived from the expression profiling of a panel of 21 genes (Oncotype DX) that provides estimates of 10-year distant recurrence risk and predicts the likelihood of benefiting from chemotherapy. This genetic expression profiling test has become more widely used in the

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