RevisiónPotencial rol protector del óxido nítrico y Hsp70 asociado a alimentos funcionales en la aterosclerosisPotential protective role of nitric oxide and Hsp70 linked to functional foods in the atherosclerosis
Section snippets
Introducción
La ateroesclerosis como entidad patológica emergente en los países industrializados responde a un síndrome caracterizado por el depósito y la infiltración de sustancias lipídicas en las paredes de las arterias de mediano y grueso calibre. Además, provoca inflamación, multiplicación y migración de las células musculares lisas condicionando el estrechamiento de la luz arterial1, para finalmente conducir a la aparición de enfermedades cardiovasculares (ECV). En el proceso inflamatorio crónico
Óxido nítrico y Hsp70 en aterosclerosis
El NO, una especie reactiva del nitrógeno de vida media ultracorta, participa como factor regulador de una diversa gama de funciones fisiológicas como el control de la resistencia vascular, la neurotransmisión y la modulación de procesos inflamatorios, entre otras11, 26, 27, 28, 29, 30. Bioquímicamente y a nivel citosólico, el NO es una molécula sintetizada por enzimas NOS con L-arginina, NADPH y O2 como sustratos básicos31. Por otro lado, también se ha descrito una producción mitocondrial
Alimentos funcionales y salud cardiovascular
Si bien el concepto de alimentos funcionales fue introducido, es menester destacar que en la actualidad existen controversias respecto a trazar una línea que precise las características específicas de este grupo de alimentos que los diferencien del resto. En consecuencia, no se encuentra una definición de alimentos funcionales que sea universalmente aceptada y, por lo tanto, son escasas las regulaciones específicas en países de occidente63. Diferente es la situación en oriente, donde los
Alimentos funcionales, óxido nítrico y Hsp70 en aterosclerosis
El estado de conocimiento actual discute sobre las múltiples causas de la enfermedad ateroesclerótica; sin embargo, la inflamación y el estrés oxidativo juegan un papel fundamental en la patogénesis de la disfunción endotelial que se atribuye comúnmente a una alteración en la disponibilidad de NO. En adición, Hsp70 protegería a los elementos celulares de la lesión mediante la reducción de la oxidación, la inflamación y la apoptosis81. Por lo tanto, existen evidencias concretas que sugieren al
Conclusiones y perspectivas
El estado de conocimiento actual reconoce un importante número de causas de la enfermedad ateroesclerótica. Sin embargo, la inflamación y el estrés oxidativo destacan como determinantes fundamentales en la patogénesis de la disfunción endotelial atribuida comúnmente a una alteración en la disponibilidad de NO. En adición, Hsp70 protegería a los elementos celulares de la lesión mediante la reducción de la oxidación, la inflamación y la apoptosis. De interés, se encuentran en constante revisión
Protección de personas y animales
Los autores declaran que para esta investigación no se han realizado experimentos en seres humanos ni en animales.
Confidencialidad de los datos
Los autores declaran que han seguido los protocolos de su centro de trabajo sobre la publicación de datos de pacientes.
Derecho a la privacidad y consentimiento informado
Los autores declaran que en este artículo no aparecen datos de pacientes.
Conflicto de intereses
Los autores declaran no tener ningún conflicto de intereses potencial con respecto a la investigación, la autoría y/o la publicación de este artículo de revisión.
Bibliografía (95)
- et al.
Thematic review series: The immune system and atherogenesis. Cytokines affecting endothelial and smooth muscle cells in vascular disease
J Lipid Res.
(2005) Laboratory assessment of cardiometabolic risk in overweight and obese children
Clin Biochem.
(2015)- et al.
Targeting NADPH oxidases in vascular pharmacology
Vascul Pharmacol.
(2012) - et al.
Pin1 inhibitor Juglone prevents diabetic vascular dysfunction
Int J Cardiol.
(2016) - et al.
Mediators and mechanisms of heat shock protein 70 based cytoprotection in obstructive nephropathy
Cell Stress Chaperones.
(2015) - et al.
Hsp70/nitric oxide relationship in apoptotic modulation during obstructive nephropathy
Cell Stress Chaperones.
(2008) - et al.
Recent insights on the mechanisms of liver preconditioning
Gastroenterology.
(2003) - et al.
Heat shock protein 70 and antibodies to heat shock protein 60 are associated with cerebrovascular atherosclerosis
Clin Biochem.
(2016) - et al.
Endothelial nitric oxide synthase induces heat shock protein HSPA6 (HSP70B’) in human arterial smooth muscle cells
Nitric Oxide.
(2016) - et al.
The regulation of mitochondrial oxygen uptake by redox reactions involving nitric oxide and ubiquinol
J Biol Chem.
(1999)
Mitochondrial metabolic states regulate nitric oxide and hydrogen peroxide diffusion to the cytosol
Biochim Biophys Acta.
Reduced ventromedial hypothalamic neuronal nitric oxide synthase and increased sensitivity to NOS inhibition in dietary obese rats: Further evidence of a role for nitric oxide in the regulation of energy balance
Brain Res.
An integrated view of insulin resistance and endothelial dysfunction
Endocrinol Metab Clin N Am.
H+-ATPase activity on unilateral ureteral obstruction: Interaction of endogenous nitric oxide and angiotensin II
Kidney Int.
Role of endogenous nitric oxide in unilateral ureteropelvic junction obstruction in children
Kidney Int.
Losartan modulation on NOS isoforms and COX-2 expression in early renal fibrogenesis in unilateral obstruction
Kidney Int.
Cytoprotective role of nitric oxide associated with Hsp70 expression in neonatal obstructive nephropathy
Nitric Oxide.
The Nrf2-Keap1 cellular defense pathway and heat shock protein 70 (Hsp70) response. Role in protection against oxidative stress in early neonatal unilateral ureteral obstruction (UUO)
Cell Stress Chaperones.
Hsp72 chaperone function is dispensable for protection against stress-induced apoptosis
Cell Stress Chaperones.
The importance of the cellular stress response in the pathogenesis and treatment of type 2 diabetes
Cell Stress Chaperones.
Increased serum HSP70 levels are associated with the duration of diabetes
Cell Stress Chaperones.
Antioxidant status, lipid peroxidation and nitric oxide end products in patients of type 2 diabetes mellitus with nephropathy
Clin Biochem.
HSF1 and constitutively active HSF1 improve vascular endothelial function (heat shock proteins improve vascular endothelial function)
Atherosclerosis.
Functional food. Product development, marketing and consumer acceptance. A review
Appetite.
Functional foods: Benefits, concerns and challenges. A position paper from the American Council on Science and Health
J Nutr.
Home-cooked garlic remains a healty food
J Funct Foods.
The chemical diversity and distribution of glucosinolates and isothiocyanates among plants
Phytochemistry.
Crucial facts about health benefits of popular cruciferous vegetables
J Funct Foods.
Fruit and vegetable intake and risk of cardiovascular disease: The women's health study
Am J Clin Nutr.
Mechanisms underlying the antihypertensive effects of garlic bioactives
Nutr Res.
Antioxidants and vascular health
Life Sci.
The role of adiponectin in cardiometabolic diseases: Effects of nutritional interventions
J Nutr.
Low plasma levels of HSP70 in patients with carotid atherosclerosis are associated with increased levels of proteolytic markers of neutrophil activation
Atherosclerosis
Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity
Mol Aspects Med.
Therapeutic effect of S-allylmercaptocysteine on acetaminophen-induced liver injury in mice
Eur J Pharmacol.
Global burden of cardiovascular diseases. Part I: General considerations, the epidemiologic transition, risk factors, and impact of urbanization
Circulation.
Cohort profile: The Men Androgen Inflammation Lifestyle Environment and Stress (MAILES) study
Int J Epidemiol.
Consolidated and emerging inflammatory markers in coronary artery disease
World J Exp Med.
Obesity, hypertension and hypercholesterolemia as risk factors for atherosclerosis leading to ischemic events
Curr Med Chem.
Mitochondrial oxidative stress, mitochondrial DNA damage and their role in age-related vascular dysfunction
Int J Mol Sci.
Metabolic syndrome, aging and involvement of oxidative stress
Aging Dis.
S-Nitrosylation and uncompetitive/fast off-rate (UFO) drug therapy in neurodegenerative disorders of protein misfolding
Cell Death Differ.
Mechanisms of hepatoprotection by nitric oxide
Ann N Y Acad Sci.
Recent advances in gastrointestinal pathophysiology: Role of heat shock proteins in mucosal defense and ulcer healing
Biol Pharm Bull.
Heat shock proteins: Mediators of atherosclerotic development
Curr Drug Targets.
Mediterranean nutraceutical foods: Strategy to improve vascular ageing
Mech Ageing Dev.
Health effects of changes in the structure of dietary macronutrients intake in western societies
Rocz Panstw Zakl Hig.
Cited by (10)
Anti-inflammatory, antioxidant, antihypertensive, and antiarrhythmic effect of indole-3-carbinol, a phytochemical derived from cruciferous vegetables
2022, HeliyonCitation Excerpt :Recent research suggests this signaling pathway as a valid hypothesis that justifies the use of so-called functional foods as a strategy to prevent vascular aging and the development of atherosclerosis (Kitada et al., 2016). Functional foods stand out for their high content of active compounds (phytochemicals) and show beneficial properties in relation to health (Camargo and Manucha, 2017). One of these compounds is indole-3-carbinol (I3C), which is found in vegetables belonging to the cruciferous genus, such as broccoli and cabbage (Licznerska and Baer-Dubowska, 2016).
Phytochemical profile and functionality of Brassicaceae species
2020, Food BioscienceCitation Excerpt :Some authors have reported that ITC can lower the incidences of different cancers (Dinkova-Kostova & Kostov, 2012). The chemopreventive properties of ITC are shown by their participation in multiple anticancer mechanisms such as modifications of the chemical carcinogenesis process due to changes in the activities of drug-metabolizing enzymes, induction of cell cycle arrest and apoptosis, inhibition of angiogenesis and metastasis, changes in histone acetylation status, as well as antioxidant, anti-inflammatory, and immunomodulatory activities (Camargo & Manucha, 2016; Dinkova-Kostova & Kostov, 2012). The characterization of the ITC's antioxidant properties is significant because they may protect the human body against the oxidative damage mediated by reactive oxygen species (ROS).
Allicin pharmacology: Common molecular mechanisms against neuroinflammation and cardiovascular diseases
2020, Life SciencesCitation Excerpt :OSCs increase the expression of HSPs as part of its antioxidant protective effect [8]. For example, our laboratory has previously discussed the potential protective role of HSP70 linked to functional foods in atherosclerosis [110]. In addition to its known classic antioxidant effects, the mitochondrial protection associated with HSP70 supports an additional mechanism that involves translocase of the outer mitochondrial membrane 70 (TOM70), with the mitochondrial function being required to correct HSP70 interaction with TOM70 [111].
Heat shock protein 70 accelerates atherosclerosis by downregulating the expression of ABCA1 and ABCG1 through the JNK/Elk-1 pathway
2018, Biochimica et Biophysica Acta - Molecular and Cell Biology of LipidsCitation Excerpt :For instance, the levels of HSP70, HSP65, and HSP27 are all increased in patients with vascular disease [51,55,57]. It has been reported that HSP70 accelerates the progression of atherosclerosis [30,55,56,58,59]. However, the detailed underlying mechanisms, especially the potential effects of HSP70 on lipid metabolism and RCT and the related pathogenesis of atherosclerosis, have yet to be determined.
Analytical methods for bioactive sulfur compounds in Allium: An integrated review and future directions
2017, Journal of Food Composition and AnalysisCitation Excerpt :Garlic consumption is associated with decreased risk of some types of cancer, particularly those of the gastrointestinal tract (Guercio et al., 2014; Nicastro et al., 2015; Omar and Al-Wabel, 2010). Preclinical and clinical evidence demonstrated that garlic consumption can reduce risks associated with cardiovascular diseases (CVD), by lowering cholesterol level, inhibiting platelet aggregation, and lowering blood pressure (Bradley et al., 2016; Camargo and Manucha, 2016; Cavagnaro et al., 2007; Sikand et al., 2015). In addition to these cancer- and cardio-protective effects, various other biological activities have been reported for garlic, including antimicrobial, antioxidant, and anti-inflammatory properties (Block, 2010; Borlinghaus et al., 2014; Charu et al., 2014; Suvarna and Rajagopalan, 2015).
Chaperone duality: the role of extracellular and intracellular HSP70 as a biomarker of endothelial dysfunction in the development of atherosclerosis
2022, Archives of Physiology and Biochemistry