14 - Recent Advances in Self-Emulsifying Drug-Delivery Systems for Oral Delivery of Cancer Chemotherapeutics

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Abstract

Drug-delivery scientists are striving to improve the oral bioavailability of chemotherapeutic agents which will radically change the current regimen of chemotherapy and be a key step towards “chemotherapy at home.” Recently much attention has been focused on self-emulsifying drug-delivery systems (SEDDS), which are composed of oils, surfactants, and cosolvent, and gaining wide recognition in facilitating oral absorption of poorly aqueous soluble agents. These drug-delivery systems are designed by using ternary phase diagrams and high-throughput screening systems with specific ratios of excipients. Following their oral administration, these systems form oil in water (o/w) emulsions due to the mild agitation in the fluid of gastrointestinal milieu. Further, these systems have the ability to modulate the P-glycoprotein (P-gp) mediated efflux that decreases gut metabolism by enzymes of cytochrome P450 system, and bypass the hepatic first-pass effect, thereby facilitating absorption of chemotherapeutic agents via intestinal lymphatic pathways. This chapter will provide the reader an updated account of the potential for self-emulsifying delivery systems in the enhancement of oral bioavailability of cancer chemotherapeutic agents. Further, it also covers recent advances in the design of self-emulsifying delivery systems, their characterization, and potential role in combination chemotherapy.

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