Nanocarriers and Their Potential Application as Antimicrobial Drug Delivery

doi:10.1016/B978-0-323-46152-8.00007-X

Nanostructures for Antimicrobial Therapy

Micro and Nano Technologies

2017, Pages 169-202

Nanostructures for Antimicrobial Therapy

https://doi.org/10.1016/B978-0-323-46152-8.00007-X Get rights and content

Abstract

Since their introduction into therapy, antimicrobial drugs have made significant gains to kill or inhibit the growth of bacteria and other microbes. Despite the wide success of these drugs, the treatment of many infections still faces significant challenges. The clinical failure of antimicrobial therapy is linked with low bioavailability, poor penetration to microbial infection sites, and the side effects of antimicrobial drugs, as well as the antimicrobial resistance properties of microbes. Recently, nanotechnology has been presented as a promising approach to encapsulate antimicrobial drugs to enhance bioavailability, avoid drug toxicity, and reduce antimicrobial resistance. Nanocarriers have unique physicochemical properties such as ultrasmall and controllable size, large surface area-to-mass ratio, high reactivity, and functionalizable structure. These properties can be applied to facilitate the administration of antimicrobial drugs, thereby overcoming some of the limitations in traditional antimicrobial therapeutics. This chapter focuses on the properties of various nanocarriers including liposomes, solid lipid nanoparticles, polymeric nanoparticles, dendrimers, and metal nanoparticles as promising tools for antimicrobial drugs. The potential application of these nanoparticles is also reviewed.

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Citation Excerpt :
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Chapter 7 - Nanocarriers and Their Potential Application as Antimicrobial Drug Delivery

Abstract