Chapter 17 - Oxidative and Nitrosative Stress in Chronic Cholestasis
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Poly (ADP-Ribose) polymerase-1 (PARP-1) overactivity plays a pathogenic role in bile acids-induced nephrotoxicity in cholestatic rats
2020, Toxicology LettersCitation Excerpt :It has been well-documented that oxidative stress is a fundamental mechanism involved in the pathogenesis of CN (Bomzon et al., 1997; Heidari et al., 2019). Oxidative stress is closely related to inflammatory response, mitochondrial impairment, and tissue fibrosis (Grattagliano et al., 2017; Woolbright and Jaeschke, 2012). In the current study, the relationship between oxidative stress biomarkers, inflammatory response, tissue fibrosis, and PARP-1 expression and activity has been investigated in the renal tissue of cholestatic animals.
Agmatine alleviates hepatic and renal injury in a rat model of obstructive jaundice
2020, PharmaNutritionCitation Excerpt :Interestingly, Cecilia et al. also found a correlation between oxidative stress and the progression of jaundice-related renal dysfunction in humans [36]. The release of nitric oxide (NO) and nitrosative stress also seem to play an essential role in the pathogenesis of cholestasis-induced organ injury [85,86]. The protective effects of agmatine have been repeatedly mentioned in previous studies.
Ovothiol-a isolated from sea urchin eggs suppress oxidative stress, inflammation, and dyslipidemia resulted in restoration of liver activity in cholestatic rats
2022, Biointerface Research in Applied ChemistryCellular and mitochondrial taurine depletion in bile duct ligated rats: a justification for taurine supplementation in cholestasis/cirrhosis
2022, Clinical and Experimental HepatologyApoptosis-inducing factor plays a role in the pathogenesis of hepatic and renal injury during cholestasis
2021, Naunyn-Schmiedeberg's Archives of Pharmacology