Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs

Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs

Formulation Challenges and Potential Benefits
2017, Pages 69-94
Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs

Chapter 3 - Microemulsions and Nanoemulsions as Carriers for Delivery of NSAIDs

https://doi.org/10.1016/B978-0-12-804017-1.00003-0Get rights and content

Abstract

This chapter reviews current progress in development of microemulsion- and nanoemulsion-based drug delivery systems as carriers for nonsteroidal anti-inflammatory drugs (NSAIDs) which are members of class II active pharmaceutical ingredients according to the Biopharmaceutical Classification System (e.g., ibuprofen, diclofenac, ketoprofen, celecoxib, etodolac). Thermodynamical and physicochemical considerations on microemulsions and nanoemulsions are presented concisely. The main experimental approaches in design of microemulsion/nanoemulsion carriers as well as their preconcentrates (self-micro/nanoemulsifying systems) are described. The performances of the characterization techniques employed in evaluation of self-micro/nanoemulsification process and identification and differentiation of microemulsion/nanoemulsion carriers are commented. The potential advantages of NSAIDs encapsulation by using microemulsion/nanoemulsion carriers, including development of physically stable pharmaceutical dosage form with high drug loading capacity, dispersibility, rate and extent of absorption, and thus increased bioavailability, are illustrated by observations and conclusions derived from the extensive results of the relevant studies in this field.

References (0)

Cited by (10)

  • Computer-aided formulation development of microemulsion drug delivery systems

    2023, Computer-Aided Applications in Pharmaceutical Technology: Delivery Systems, Dosage Forms, and Pharmaceutical Unit Operations
  • Nanoformulations applied to the delivery of phenolic compound

    2022, Phytochemical Nanodelivery Systems as Potential Biopharmaceuticals
  • Synthesis and characterization of a nanoemulsion system for solubility enhancement of poorly water soluble non-steroidal anti-inflammatory drugs

    2021, Journal of Molecular Liquids
    Citation Excerpt :

    However, the majority of these drugs are poorly-water soluble, leading to compromised bioavailability and hence limited therapeutic activity [3–5]. The poor solubility is also a rate-limiting step in the absorption of orally administered drugs causing a major obstacle in the rapid onset of action [6,7]. Therefore, in recent years there has been an ever-growing interest in smart drug delivery techniques to improve the aqueous solubility of NSAIDs to achieve intended therapeutic efficacy and minimize the adverse effects [1,8,9].

  • Self-Generating nano-emulsification techniques for alternatively-routed, bioavailability enhanced delivery, especially for anti-cancers, anti-diabetics, and miscellaneous drugs of natural, and synthetic origins

    2020, Journal of Drug Delivery Science and Technology
    Citation Excerpt :

    In another study, the optimized ibuprofen SNEDDS formulation holding 50:30:20 (w/w) ratio of the essential oil from lemon, surfactant cremophor RH40, and the co-surfactant transcutol HP, significantly increased the drug release when equated with ibuprofen suspension. Therefore, SNEDDS technology appears to effectively control the drug release rate despite their low water solubility, which is nonetheless recommended for relatively improving the on-site availability of lipophilic drugs [225,226]. Flurbiprofen (Ansaid®, Upjohn), another NSAID, has a low aqueous solubility drug.

  • Nanotechnological paradigms for neurodegenerative disease interventions

    2020, Advanced 3D-Printed Systems and Nanosystems for Drug Delivery and Tissue Engineering
View all citing articles on Scopus
View full text