Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs
Chapter 3 - Microemulsions and Nanoemulsions as Carriers for Delivery of NSAIDs
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Computer-aided formulation development of microemulsion drug delivery systems
2023, Computer-Aided Applications in Pharmaceutical Technology: Delivery Systems, Dosage Forms, and Pharmaceutical Unit OperationsNanoformulations applied to the delivery of phenolic compound
2022, Phytochemical Nanodelivery Systems as Potential BiopharmaceuticalsSynthesis and characterization of a nanoemulsion system for solubility enhancement of poorly water soluble non-steroidal anti-inflammatory drugs
2021, Journal of Molecular LiquidsCitation Excerpt :However, the majority of these drugs are poorly-water soluble, leading to compromised bioavailability and hence limited therapeutic activity [3–5]. The poor solubility is also a rate-limiting step in the absorption of orally administered drugs causing a major obstacle in the rapid onset of action [6,7]. Therefore, in recent years there has been an ever-growing interest in smart drug delivery techniques to improve the aqueous solubility of NSAIDs to achieve intended therapeutic efficacy and minimize the adverse effects [1,8,9].
Self-Generating nano-emulsification techniques for alternatively-routed, bioavailability enhanced delivery, especially for anti-cancers, anti-diabetics, and miscellaneous drugs of natural, and synthetic origins
2020, Journal of Drug Delivery Science and TechnologyCitation Excerpt :In another study, the optimized ibuprofen SNEDDS formulation holding 50:30:20 (w/w) ratio of the essential oil from lemon, surfactant cremophor RH40, and the co-surfactant transcutol HP, significantly increased the drug release when equated with ibuprofen suspension. Therefore, SNEDDS technology appears to effectively control the drug release rate despite their low water solubility, which is nonetheless recommended for relatively improving the on-site availability of lipophilic drugs [225,226]. Flurbiprofen (Ansaid®, Upjohn), another NSAID, has a low aqueous solubility drug.
Nanotechnological paradigms for neurodegenerative disease interventions
2020, Advanced 3D-Printed Systems and Nanosystems for Drug Delivery and Tissue EngineeringNanoemulsion preparation, characterization, and application in the field of biomedicine
2019, Nanoarchitectonics in Biomedicine