5.03 - Carboxylic Esters and Lactones

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There are an extremely large number of procedures for the synthesis of carboxylic esters and lactones. This review attempts to summarize some of the more useful techniques. For example, esters can be prepared by direct esterification using a carboxylic acid and an alcohol. The synthesis of lactones can be achieved using many of the procedures used in the formation of carboxylic esters. One of the most useful techniques for lactone synthesis is macrolactonization, and a large number of natural products have been synthesized using this approach.

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Benjamin R. Buckley was born in Nottingham, studied at Manchester Metropolitan University, where he obtained a B.Sc. in 1999 and Loughborough University where he obtained his Ph.D. in 2003 under the supervision of Professor Philip C. Bulman Page. Following this he worked as Postdoctoral Research Associate with Professor Philip C. Bulman Page for a further year and took up his present position as a Postdoctoral Research Fellow in the Page group at Loughborough University in January 2004. His scientific interests include all aspects of asymmetric synthesis, in particular asymmetric organocatalysis.

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