Current Biology
DispatchEmerging families of cytokines and receptors
References (29)
- et al.
A structural superfamily of growth factors containing a cystine knot motif
Cell
(1993) - et al.
Crystal structure of the soluble human 55 kD TNF receptor-human TNF β complex: implications for TNF receptor activation
Cell
(1993) - et al.
A new superfamily of cell surface proteins related to the nerve growth factor receptor
Immunol Today
(1991) - et al.
When apoptosis fails
Curr Biol
(1992) - et al.
Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease
Cell
(1992) - et al.
Construction and evaluation of a hncDNA library of human 12p transcribed sequences derived from a somatic cell hybrid
Genomics
(1993) - et al.
Lymphotoxin β, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface
Cell
(1993) - et al.
CD40 and its ligand, an essential ligand-receptor pair for thymus-dependent B-cell activation
Immunol Today
(1992) - et al.
CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF
Cell
(1993) - et al.
Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor
Cell
(1993)
The structure of human lymphotoxin (tumor necrosis factor-β) at 1.9 Å resolution
J Biol Chem
Anatomy and evolution of proteins displaying the viral capsid jellyroll topology
J Mol Biol
Tumor necrosis factor's cytotoxic activity is signaled by the p55 TNF receptor
Cell
A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen
J Biol Chem
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The Immunobiology of the Interleukin-12 Family: Room for Discovery
2019, ImmunityCitation Excerpt :As mentioned, IL-6 and the heterodimeric cytokines IL-12, IL-23, and IL-27 belong to the class I hematopoietin family of cytokines, based on their shared four-α-helix-bundle motif. This motif is oriented in an up-up-down-down topology and is only found in helical cytokines (Bazan, 1993, 1990; Oppmann et al., 2000). The β subunits of the heterodimers are linked to the α subunits through a disulfide bond.
An improved understanding of TNFL/TNFR interactions using structure-based classifications
2012, Trends in Biochemical SciencesCitation Excerpt :It is the first time an automated classification has been reported to be in agreement with receptor architecture. By contrast, this new classification is in slight disagreement with previous approaches [9,12,15,16] that explicitly relied on the comparison of disulfide bridge networks to define the classes. Using the HMM methodology described earlier, we systematically annotated all of the human TNFR family members without known structures (Figure 5) (Table S3 in the supplementary material online).
The mechanism of shared but distinct CSF-1R signaling by the non-homologous cytokines IL-34 and CSF-1
2012, Biochimica et Biophysica Acta - Proteins and ProteomicsCitation Excerpt :The six α‐helices (α1 for residues 38–57, α2 for 74–82, α3 for 87–108, α4 for 115–134, α5 for 140–150 and α6 for 161–180) in the bundle are oriented in an “up–down–up–down–up–down “ fashion (Fig. 1C), with a kink disrupting the first helix into two stretches. The longer α1, α3, α4 and α6 helices roughly correspond to the four-helix core structure characteristic of helical cytokines, including CSF-1 [19]. The other two helices (α2 and α5), packed against α3 and α6, are associated with the 4 longer helices through continuous hydrophobic interactions.
T-RMSD: A Fine-grained, Structure-based Classification Method and its Application to the Functional Characterization of TNF Receptors
2010, Journal of Molecular BiologyStructure and Function of Tumor Necrosis Factor at the Cell Surface
2003, Handbook of Cell Signaling: Volume 1-3