Current Biology
Volume 3, Issue 9, 1 September 1993, Pages 603-606
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Emerging families of cytokines and receptors

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  • The Immunobiology of the Interleukin-12 Family: Room for Discovery

    2019, Immunity
    Citation Excerpt :

    As mentioned, IL-6 and the heterodimeric cytokines IL-12, IL-23, and IL-27 belong to the class I hematopoietin family of cytokines, based on their shared four-α-helix-bundle motif. This motif is oriented in an up-up-down-down topology and is only found in helical cytokines (Bazan, 1993, 1990; Oppmann et al., 2000). The β subunits of the heterodimers are linked to the α subunits through a disulfide bond.

  • An improved understanding of TNFL/TNFR interactions using structure-based classifications

    2012, Trends in Biochemical Sciences
    Citation Excerpt :

    It is the first time an automated classification has been reported to be in agreement with receptor architecture. By contrast, this new classification is in slight disagreement with previous approaches [9,12,15,16] that explicitly relied on the comparison of disulfide bridge networks to define the classes. Using the HMM methodology described earlier, we systematically annotated all of the human TNFR family members without known structures (Figure 5) (Table S3 in the supplementary material online).

  • The mechanism of shared but distinct CSF-1R signaling by the non-homologous cytokines IL-34 and CSF-1

    2012, Biochimica et Biophysica Acta - Proteins and Proteomics
    Citation Excerpt :

    The six α‐helices (α1 for residues 38–57, α2 for 74–82, α3 for 87–108, α4 for 115–134, α5 for 140–150 and α6 for 161–180) in the bundle are oriented in an “up–down–up–down–up–down “ fashion (Fig. 1C), with a kink disrupting the first helix into two stretches. The longer α1, α3, α4 and α6 helices roughly correspond to the four-helix core structure characteristic of helical cytokines, including CSF-1 [19]. The other two helices (α2 and α5), packed against α3 and α6, are associated with the 4 longer helices through continuous hydrophobic interactions.

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