Activation-induced apoptosis in lymphocytes

doi:10.1016/0952-7915(94)90130-9

Current Opinion in Immunology

Volume 6, Issue 3, June 1994, Pages 476-487

https://doi.org/10.1016/0952-7915(94)90130-9 Get rights and content

Abstract

Activation-induced apoptosis has been proposed as a mechanism for purging the immune repertoire of anti-self specificities, not only in development but also during the generation of somatic mutation in germinal centers. The pathways involved in driving immature and mature T and B cells to programmed cell death are reviewed with respect to two hypotheses, the pre-emptive death model, in which certain signals are obligatory for programmed cell death, and the two signal: death/survival model. Depending on the system, some data support the former pathway, in which certain signals are obligatory for programmed cell death, whereas other data are consistent with the two signal hypothesis. Moreover, recent data suggests that the c-myc protein plays a pivotal role in controlling this process. Finally conflicting roles of protein kinases, bcl-2 and p53 are reviewed and contrasted for involvement in activation-induced cell death in T and B lymphocytes.

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Activation-induced apoptosis in lymphocytes

Abstract

Clin Immunol and Immunopathol

Cell

Eur J Immunol

J Exp Med

Cell

Eur J Immunol

Nature

Eur J Immunol

Cell

Gene Dev

Blood

Antibodies to CD3/T Cell Receptor Complex Induce by Apoptosis in Immature T Cells in Thymic Cultures

Nature

Cyclosporin A Inhibits Activation-induced Cell Death in T Cell Hybridomas and in Thymocytes

Nature

In Vivo Administration of Antibodies to the CD3/T Cell Receptor Complex Induces Cell Death (Apoptosis) in Immature Thymocytes

J Immunol

Induction by Antigen of Intrathymic Apoptosis of CD4+CD8+ TCR lo Thymocytes in Vivo

Science

Clonal Deletion of Immature CD4+8+ Thymocytes in Suspension Culture by Extrathymic Antigen-presenting Cells

Nature

Antigen-induced Apoptosis in Developing T Cells: a Mechanism for Negative Selection of the T Cell Receptor Repertoire

Eur J Immunol

In Vivo Induction of Apoptosis in Immature Thymocytes by Staphylococcal Enterotoxin B

J Immunol

Negative Selection of Thymocytes. A Novel Polymcrase Chain Reaction-based Molecular Analysis Detects Requirements for Macromolecular Synthesis

J Immunol

Programmed Death of Autoreac-tive Thymocytes

Nature

Calcium-dependent Killing of Immature Thymocytes by Stimulation via the CD3/T Cell Receptor Complex

J Immunol

CD4+CD8+ Thymocytes are Susceptible to DNA Fragmentation Induced by Phorbol Ester, Cal cium Ionophorc and Anti-CD3 Antibody

Eur J Immunol

Activation-induced Apoptosis in Lymphoid Systems

Sem Immunol

No Requirement for p56lck in the Antigen-stimulated Clonal Deletion of Thymocytes

Science

In vivo and in vitro Clonal Deletion of Double-Positive Thymocytcs

J Exp Med

In Vivo Calcium Elevations in Thymocytes with T Cell Receptors that Arc Specific for Self Ligands

Science

Clonal Deletion of Autorcactive B Lymphocytes in Bone Marrow Chimeras

Antigen-induced Apoptotic Death of Ly-1 B Cells Responsible for Autoimmune Disease in Transgenic Mice

Nature

A Role for Immunoglobulin D: Interference with Tolerance Induction

Eur J Immunol

Can Peritoneal B Cells be Rendered Unresponsive?

Int Immunol

Cell Growth Cycle Block of T Cell Hybridomas upon Activation with Antigen

J Exp Med

Inhibition of Transformed T Cell Growth in Vitro by Monoclonal Antibodies Directed against Distinct Activating Molecules

J Immunol

The Cell Cycle Block and Lysis of an Activated T Cell Hybridoma Are Distinct Processes with Different Ca2+ Requirements and Sensitivity to Cyclosporinc A

J Immunol

Activation-driven T Cell Death. I. Requirements for de Novo Transcription and Translation and Association with Genome Fragmentation

J Immunol

T Cell Receptor-mediated DNA Fragmentation and Cell Death in T Cell Hybridomas

J Immunol

Activation Induced Cell Death in T Cell Hybridomas is Due to Apoptosis: Morphological Aspects and DNA Fragmentation

J Immunol

Effect of Accessory Cells on Stimulation of Murinc T-Ccll Leukemia with Antibodies to the CD3/T Cell Antigen Receptor Complex

Jpn J Cancer Res

Anti-Immunoglobulins Induce Death by Apoptosis in WEHI-231 B Lymphoma Cells

Eur J Immunol

Anti-immunoglobulin Antibodies Induce Apoptosis in Immature B Cell Lymphomas

Eur J Immunol

A Polyclonal Model for B Cell Tolerance. I. Fc-dependent and Fc-independent Induction of Nonresponsiveness by Pretreatment of Normal Splenic B Cells with Anti-Ig

J Immunol

Peripheral Clonal Elimination of Functional T Cells

Science

Programmed Cell Death and Extrathymic Reduction of Vβ8+ CD4+ T Cells in Mice Tolerant to Staphylococcus Aureus Enterotoxin B

Nature

Expansion and Clonal Deletion of Peripheral T Cells Induced by Bacterial Superantigen is Independent of the Interleukin-2 Pathway

Eur J Immunol

Interleukin-2 Programs Mouse αβ T Lymphocytes for Apoptosis

Nature

Religation of the T Cells, Receptor after Primary Activation of Mature T Cells Inhibits Proliferation and Induces Apoptosic Cell Death

J Immunol

Induction by Antigen of Intrathymic Apoptosis of CD4⁺CD8⁺ TCR lo Thymocytes in Vivo

Clonal Deletion of Immature CD4⁺8⁺ Thymocytes in Suspension Culture by Extrathymic Antigen-presenting Cells

CD4⁺CD8⁺ Thymocytes are Susceptible to DNA Fragmentation Induced by Phorbol Ester, Cal cium Ionophorc and Anti-CD3 Antibody

The Cell Cycle Block and Lysis of an Activated T Cell Hybridoma Are Distinct Processes with Different Ca²⁺ Requirements and Sensitivity to Cyclosporinc A

Programmed Cell Death and Extrathymic Reduction of Vβ8⁺ CD4⁺ T Cells in Mice Tolerant to Staphylococcus Aureus Enterotoxin B