Positive and negative selection of the αβ T-cell repertoire in vivo

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Abstract

The selection of developing and mature αβ T cells, by intrathymic and extra-thymic ligands expressed on cells of hemopoietic and other origins, has been studied in a variety of systems. These experiments have increased our knowledge of the selection of αβ T cells in the thymus, in the presence or absence of specific peptides bound to MHC, and also made clear that additional selective mechanisms exist outside the thymus that can be exploited to silence mature T cells.

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