Original contributionAging, cytochrome oxidase activity, and hydrogen peroxide release by mitochondria☆
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2015, Biochimica et Biophysica Acta - BioenergeticsCitation Excerpt :Inhibition of this step by myxothiazol has an effect on the ROS production rate that is identical to the effect of AA in model L (Fig. 5B,D) which is compatible with experimental observations of the myxothiazol effect on ROS production in liver mitochondria [71]. However, there are experimental observations in rat heart and brain [70] and insect muscle [86] mitochondria which showed a smaller increase in ROS production induced by myxothiazol alone than AA alone. Moreover, these observations show inhibition of the ROS production rate by myxothiazol in the presence of AA.
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This research was supported by grant RO1AG7657 from the National Institutes of Health—National Institute on Aging.
Copyright © 1993 Published by Elsevier Inc.