Positively charged submicron emulsions — a new type of colloidal drug carrier

doi:10.1016/0378-5173(93)90237-A

International Journal of Pharmaceutics

Volume 96, Issues 1–3, 31 July 1993, Pages R1-R6

https://doi.org/10.1016/0378-5173(93)90237-A Get rights and content

Abstract

A positively charged submicron emulsion was prepared and stabilized by forming a mixed film comprising phospholipids, poloxamer and stearylamine at the o/w interface of the oil droplets. This was confirmed concomitantly by the selective adsorption of the thiocyanate anion and the lack of adsorption of Ca²⁺ onto the emulsified oil droplets of the actual emulsions. The incorporation of various drugs in the new type of submicron emulsions altered neither the nature of the surface charge nor the mean droplet size. These results clearly demonstrated that the positively charged submicron emulsion can be used as a new type of colloidal drug carrier.

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¹: Affiliated with the David R. Bloom Center for Pharmacy.

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Rapid communicationPositively charged submicron emulsions — a new type of colloidal drug carrier

Abstract

Int. J. Pharm.

Biochem. Biophys. Res. Commun.

Int. J. Pharm.

J. Pharm. Sci.

Biomaterials

Int. J. Pharm.

Stability of a fat emulsion based intravenous feeding mixture

Int. J. Pharm.

Lipid emulsions as drug delivery systems

Ann. NY Acad. Sci.

Rapid communication
Positively charged submicron emulsions — a new type of colloidal drug carrier