Pilocarpine bioavailability from a mucoadhesive liposomal ophthalmic drug delivery system
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2023, Nanotechnology in OphthalmologyHow liposomes pave the way for ocular drug delivery after topical administration
2022, Journal of Drug Delivery Science and TechnologyCitation Excerpt :Negative or neutral liposomes cannot be significantly useful unless they bear functional groups through which they can react with the eye's surface and show the mucoadhesive characteristic. For instance, by having carboxylic groups, carbomers can participate in hydrogen bonding with mucin [40,56]. Polyamidoamine dendrimer (PAMAM G3) has been used for coating the liposome with the aim of posterior eye drug delivery.
Colloidal nanosystems with mucoadhesive properties designed for ocular topical delivery
2021, International Journal of PharmaceuticsDoe guided chitosan based nano-ophthalmic preparation against fungal keratitis
2020, Materials Today: ProceedingsCitation Excerpt :Among the three formulations, high molecular weight chitosan (hmw) nanoparticles (NPs) shows high absorbance values which indicates their high adhesion capacity with mucin, followed by medium molecular weight chitosan (mmw) NPs and low molecular weight (lmw) NPs as the increase in chitosan molecular weight results in an increase number of positively charged units which shows stronger interactions with a negatively charged mucin particles [33]. Therefore, the increased interaction of Chitosan with mucin suggest the greater retention of the CANs on the mucous membrane of an eye [33–35]. The in-vitro drug release of an optimized CANs, high; medium; low formulations [each containing 1% API (w/v)] are presented in Fig. 7.
Comparison of response surface methodology and artificial neural network to optimize novel ophthalmic flexible nano-liposomes: Characterization, evaluation, in vivo pharmacokinetics and molecular dynamics simulation
2018, Colloids and Surfaces B: BiointerfacesCitation Excerpt :Therefore, the retention time of the drug on the cornea was prolonged. In addition, Durrani et al. [51] have confirmed that PN liposome can enhance the penetration of PN in the cornea. In conclusion, the results demonstrated that PN-FLs have sustainable retention in the pre-cornea, offering long-lasting action and improving drug permeability and thus increasing the bioavailability of PN.
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