Characterization of solid dispersions of piroxicam/polyethylene glycol 4000
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Ultrasound influence on the solubility of solid dispersions prepared for a poorly soluble drug
2016, Ultrasonics SonochemistryCitation Excerpt :The X-ray diffraction pattern of PRX shown in Fig. 7 indicates that PRX is primarily in Form I (cubic crystal). The XRPD spectra for PRX showed typical peaks of diffraction (8.66, 11.68, 12.54, 14.52, 16.68, 17.72, 21.78, 22.50, 26.80, 27.42 and 27.88°) similar to that of Form I [4,34,39,40]. According to Vrecer et al. [35], the peak 15.78° indicates the presence of Form II (needle) of PRX.
Physical characterization of drug:Polymer dispersion behavior in polyethylene glycol 4000 solid dispersions using a suite of complementary analytical techniques
2014, Journal of Pharmaceutical SciencesCitation Excerpt :Inferences made using each technique independent of the others are detailed below, followed by a summary that considers collective inferences made using complementary characterization. Pure PEG4000 recrystallized rapidly on solidification, consistent with literature reports for high‐molecular‐weight PEGs.27,28,45 PXRD patterns for PEG4000 were collected for both untreated solid, and polymer subjected to the same melt–quench cycle described for API:PEG4000 mixtures.
Formulation and in vitro absorption analysis of Rhizoma paridis steroidal saponins
2013, International Journal of PharmaceuticsCitation Excerpt :The poor solubility of drugs could be changed using dosage forms such as solid dispersions (SD) or phytosome (PHY). SD formulation with hydrophilic carriers has been a promising technique for improving the solubility, dissolution rate and the absorption of many substances as they overcome the limitations of previous approaches (Fernandez et al., 1992; Han et al., 2011; Hirasawa et al., 2003). PHY as a dosage form enhances the ability of a drug to pass across the lipid-rich biological membranes and reach circulation (Maiti et al., 2007; Marczylo et al., 2007).
Improvement of the dissolution rate of indomethacin by a cogrinding technique using polyethylene glycols of various molecular weights
2006, Journal of Drug Delivery Science and Technology