Increase of doxorubicin penetration in cultured rat hepatocytes by its binding to polymethacrylic nanoparticles☆
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Methylmethacrylate-sulfopropylmethacrylate nanoparticles with surface RMP-7 for targeting delivery of antiretroviral drugs across the blood-brain barrier
2012, Colloids and Surfaces B: BiointerfacesCitation Excerpt :Moreover, NPs can carry various kinds of drug to transport across the blood–brain barrier (BBB) [18,19]. Polymethylmethacrylate (PMMA) NPs is a highly biocompatible material, evidenced by nearly no toxicity to rat hepatocytes [20]. In addition, methylmethacrylate (MMA) could be copolymerized with monomeric cations containing quaternary ammonium, yielding structural dissimilar biopolymers with tolerable cytotoxicity to human skin fibroblasts and monkey kidney cells [21].
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Work presented at the International Symposium on “Liver Cells and Drugs”, July 7–10, 1987, Rennes, France.
Copyright © 1989 Published by Elsevier B.V.