Gastrointestinal transit of non-disintegrating tablets in fed subjects

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Abstract

The gastrointestinal transit of non-disintegrating tablets of different sizes (3–7 mm diameter) was monitored in fed subjects. Transit of the tablets was followed using the technique of γ-scintigraphy. Neither the gastric emptying nor small intestine transit of the tablets was affected by their size. However, the nature of the meal consumed had a marked effect on gastric emptying. The nature of the meal also appeared to influence the transit through the ileocaecal sphincter.

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    Present address: Paines & Byrne, Bilton Road, Greenford, Middlesex UB6 7HG, U.K.

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    Present address: Reckitt & Colman, Dansom Lane, Kingston-Upon-Hull HU8 7DS, U.K.

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    Copyright © 1989 Published by Elsevier B.V.