The effects of polyalkylcyanoacrylate nanoparticles on human normal and malignant mesenchymal cells in vitro

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Abstract

The interaction of a range of polyalkylcyanoacrylate nanoparticles with human mesenchymal malignant and normal cells was studied in vitro. The effects on cell viability and morphology (observed in transmission electron microscopy) were determined. Those nanoparticles based on polymers with shorter alkyl side chains were more toxic to the cells. Toxicity was also dependent on time, concentration, and the surfactant used in manufacture, but was independent of cell type. The adverse effects were reflected in TEM by loss of adhesion, followed by dilation of the rough endoplasmic reticulum. Perforation of the cell membrane occurred late in the sequence of damage.

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