Development of a new process for the manufacture of polyisobutylcyanoacrylate nanocapsules

doi:10.1016/0378-5173(86)90236-X

International Journal of Pharmaceutics

Volume 28, Issues 2–3, February 1986, Pages 125-132

https://doi.org/10.1016/0378-5173(86)90236-X Get rights and content

Abstract

A new process for the manufacture of nanocapsules is described. The dispersion of an alcoholic solution of isobutylcyanoacrylate and oil in water, by interfacial polymerization, allows the formation of nanocapsules with an average diameter of about 200–300 nm. Physical and technical parameters are studied: temperature of preparation, pH of aqueous phase, concentration of surfactant and ethanol. Investigated with different active molecules and particularly with a radiological tracer, nanocapsule manufacture presents some advantages: (i) preparation is easily transposable to an industrial scale; and (ii) the method allows for a high level of entrapment for lipophilic substances.

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Development of a new process for the manufacture of polyisobutylcyanoacrylate nanocapsules

Abstract

J. Pharm. Sci.

J. Pharm. Sci.

Int. J. Pharm.

Int. J. Pharm.

Biomaterials

Int. J. Pharm.

Int. J. Pharm.

Nanocapsules de polyalkylcyanoacrylates, nouveaux vecteurs de médicaments

Pharm. Ph. D.

Préparation et caractérisation de microsphères biodégradables pour chimio-embolisation

Pharm. Ph. D.

Polycyanoacrylate nanocapsules as potential lysosomotropic carriers: preparation, morphological and sorptive properties

J. Pharm. Pharmacol.

Interfacial properties of polymethyl-alpha-cyanoacrylate and polybutyl-alpha-cyanoacrylate

J. Pharm. Pharmacol.

Potentially biodegradable microcapsules with polyalkyl 2 cyanoacrylate membranes

J. Pharm. Pharmacol.