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Cited by (56)
Nanotechnology in the diagnosis of ocular diseases, drug delivery, and therapy challenges and opportunities
2023, Nanotechnology in OphthalmologyScreening of chemical linkers for development of pullulan bioconjugates for intravitreal ocular applications
2021, European Journal of Pharmaceutical SciencesCitation Excerpt :Polymers have been used to produce biodegradable nano- and microparticles, hydrogels, bioconjugates, stimuli-sensitive systems with tailored physicochemical and biopharmaceutical properties (Imperiale et al., 2018). For example, synthetic polymers used for production of intravitreal drug delivery systems include poly(alkylcyano-acrylate) (Harmia et al., 1986a; Harmia et al., 1986b), poly(lactic acid) (Bourges et al., 2003; Liu et al., 2016), poly(lactide-co-glycolic-acid) (Luo et al., 2013; Pan et al., 2011) and poly(epsilon-caprolactone) (Nasr et al., 2016), while natural polymers include chitosan (Lu et al., 2014), hyaluronic acid (Krohne et al., 2012), gelatin (Hathout and Omran, 2016), and sodium alginate (Wang et al., 2018). Drugs can be either physically or chemically loaded in the nanoparticles.
Functionalized polymers for tissue engineering and regenerative medicines
2019, Advanced Functional Polymers for Biomedical ApplicationsNanoparticles for drug delivery to the anterior segment of the eye
2017, Advanced Drug Delivery ReviewsCitation Excerpt :Hydrophobic drugs such as pilocarpine [64] and acyclovir [69], and hydrophilic drugs such as betaxolol hydrochloride [67] and amikacin sulfate [68], were successfully loaded into PACA nanoparticles. Poly(butyl cyanoacrylate) PBCA nanoparticles improved myotic response to pilocarpine in albino rabbits [64]; increased the concentration of amikacin sulfate in the cornea and aqueous humor in the presence of dextran 70,000 [68]; and enhanced the absorption of positively charged betaxolol hydrochloride with decreasing its surface zeta potential and the subsequent antiglaucoma activity of betaxolol hydrochloride, depending on the amount of the drug released [67]. Table 6 summarizes various drug-loaded PACA nanoparticles and their characteristics.
Nanotherapies for the treatment of ocular diseases
2015, European Journal of Pharmaceutics and BiopharmaceuticsCitation Excerpt :Namely, ocular drug delivery nanocarriers have shown the capacity to (i) associate a wide variety of drugs, including large biomacromolecules, (ii) reduce the degradation of labile drugs, (iii) increase the residence time of the associated drugs onto the ocular surface, and (iv) improve their interaction with the corneal and conjunctival epithelia and consequently their bioavailability [17–20]. The use of nanocarriers for ocular drug delivery started in the 80s, being our group one of the pioneers in the field [21–26]. However, as shown in Fig. 2, it has only been in the last decade that this field has grown substantially, leading to a wide variety of nanostructures and providing an improved understanding of their potential for ocular drug delivery.
Identifying polymer structures for oral drug delivery - A molecular design approach
2014, Computers and Chemical EngineeringCitation Excerpt :Poly(ortho esters) and polyanhydrides were developed as matrices for drug delivery to achieve zero-order release kinetics (Mathiowitz, 1999; Attawia et al., 2001; Chiu Li et al., 2002; Heller et al., 2002). Several other biodegradable polymer systems investigated as drug delivery matrices include polyphosphazenes (Lakshmi et al., 2003), polyphosphoesters (Zhao et al., 2003), poly(amino acids), poly(alkyl cyanoacrylates) (Harmia et al., 1986; Nicolas and Couvreur, 2009; Dossi et al., 2010), polyhydroxy alkanoates (Kassab et al., 1997; Shrivastav et al., 2013) and poly(glutamic acid) (Li et al., 1998; Yuan et al., 2010). Langer et al. proposed polyanhydrides to be ideal candidates for drug delivery applications (Rosen et al., 1983; Jain et al., 2008).
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Present address: University of Helsinki, School of Pharmacy, Fabianink. 35, SF-00170 Helsinki, Finland.