Preparation and characterisation of sustained-release ibuprofen-cetostearyl alcohol spheres
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Application of ethyl cellulose, microcrystalline cellulose and octadecanol for wax based floating solid dispersion pellets
2016, Carbohydrate PolymersCitation Excerpt :As reported in the literatures, floating ability of pellets could also be obtained successfully with low-density materials as floating assistants. The commonly used floating assistants are waxes, fatty acids, fatty oils and glycerides, such as microcrystalline wax (Vergote et al., 2001), cetostearyl alcohol (Wong, Gilligan, & Po, 1992), stearic acid (Vo et al., 2016), hydrogenated soybean oil (Chansanroj, Betz, Leuenberger, Mitrevej, & Sinchaipanid, 2007), hydrogenated vegetable oil (Wiwattanapatapee et al., 2004), Gelucire (Siepmann et al., 2006) and so on. For these floating pellets, the drug was generally mixed with the excipients for extrusion-spheronization or dispersed uniformly in the low-density materials by melt technique (melt extrusion, melt pelletization and melt coating).
Interactions during aqueous film coating of ibuprofen with Aquacoat ECD
2000, International Journal of PharmaceuticsBioavailability of ibuprofen from matrix pellets based on the combination of waxes and starch derivatives
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1996, International Journal of PharmaceuticsProcessing factors affecting particle size and in vitro drug release of sustained-release ibuprofen microspheres
1993, International Journal of Pharmaceutics