Solid colloidal drug delivery systems: Nanoparticles
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2021, Biosensors and BioelectronicsCitation Excerpt :Meanwhile, along with the rapid development of smart theranostic nanomaterial-based biosensors, emerging the problem of how to improve the positioning and circulation effectiveness of in vivo biosensing elements, as the accurate, stable, and long-term perception and transmission of diagnostic/therapeutic signals from targeted sites, as well as the controlled drug delivery to the selected positions are main factors decisively affect the clinical applications of nanobiosensors. The idea of beneficially influencing the bio-distribution and pharmacokinetics of the administrated drugs and sensing elements has led to the origination of drug delivery systems (DDSs), which include the concepts of temporal (i.e., rate of release) and spatial (i.e., site of release) control of the pharmacokinetic parameters of administrated agents by integrating them with other chemicals, administration devices or processes (Oppenheim, 1981). As early as the 1970s, it has been realized that in addition to the administration, the therapeutic effects and the long-term efficiency of continuous in vivo biosensing is determined by the attainment of an active drug and the functioning biosensing element with an appropriate concentration in the target site of the organism (Juliano, 1978).
Carbohydrate and protein based biopolymeric nanoparticles: Current status and biotechnological applications
2020, International Journal of Biological MacromoleculesCitation Excerpt :Beyond the chemically synthesized nanoparticles, polymer of biological origin offers viable route due to its different and unique characteristics such as biocompatibility, biodegradability and ease of preparation methods. More studies have been done in the area of drug delivery using the biopolymeric nanoparticles [3]. Drug efficiency and its targeting capacity are increased with the use of biopolymers [4].
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2013, Biotechnology AdvancesCitation Excerpt :As a result, the drug is localized to a greater degree on the targeted site while leaving surrounding tissues unaffected. The ideal drug delivery system delivers drug at rates finely tuned to the biological requirement of the body (Cunliffe et al., 2005; Oppenheim, 1981; Pfister and Hsieh, 1990). Due to their high specificity and efficacy, TDDS are the future in rational drug design and development.